The phosphonic acid functional group, which is characterized by a phosphorus atom bonded to three oxygen atoms (two hydroxy groups and one P=O double bond) and one carbon atom, is employed for many applications due to its structural analogy with the phosphate moiety or to its coordination or supramolecular properties. Phosphonic acids were used for their bioactive properties (drug, pro-drug), f...

Various approaches leading to mono-, diand poly-functionalized phosphonates as well as phosphoryl heterocycles were reported for the systematic study of relationship between chemical structure and biological activities of this most important class of organophosphorus compounds. Introduction Functionalization of phosphonic acid molecules opens enoi-nious possibilities of structural variation of ...

Z. Naturforsch. 58b, 106 – 110 (2003); received September 18, 2002 Benzyloxyureas (4) have been prepared by reactions of diethyl 3-benzyloxyamino-propyl-phosphonate (3) with isocyanates, potassium cyanate or 1,1’-carbonyldiimidazole / methylamine. Conversion of phosphonic esters 4 into phosphonic acids 6 by means of bromotrimethylsilane and catalytic hydrogenation of 4, 6 afforded the target co...

The activation of silent natural product gene clusters is a synthetic biology problem of great interest. As the rate at which gene clusters are identified outpaces the discovery rate of new molecules, this unknown chemical space is rapidly growing, as too are the rewards for developing technologies to exploit it. One class of natural products that has been underrepresented is phosphonic acids, ...

The Natural Product Discovery Institute contains a set of more than 30 000 fungal and actinomycete organisms that can be used for natural product discovery. The natural product library contains purified compounds, partially purified column fractions, and crude extracts from natural product-producing organisms. The collection is available for screening. This site describes a roadmap for analysin...

In this study, perfluorinated phosphonic acid modifications were utilized to modify zinc oxide (ZnO) nanoparticles because they create a more stable surface due to the electronegativity of the perfluoro head group. Specifically, 12-pentafluorophenoxydodecylphosphonic acid, 2,3,4,5,6-pentafluorobenzylphosphonic acid, and (1H,1H,2H,2H-perfluorododecyl)phosphonic acid have been used to form thin f...

Z. Naturforsch. 50b, 855-858 (1995); received November 11, 1994 Organophosphonic Acid Anhydrides, Phosphonic Acid Anhydrides, Stereochemistry, NMR Spectra The phosphonic acid anhydrides of the general formula [R P 0 2]„ have been prepared with R = Me, Et, z-Pr, r-Bu, and Ph from the corresponding phosphonic acids and their chlorides and esters. Mass spectrometric data indicate that the trimers ...

Rare earth ion-doped yttrium oxide (Y2O3) nanocrystals are nontoxic and can be prepared as upconversion materials for cellular imaging, but they do not suspend well in water. In contrast to their tendency to dissolve in acidic media, yttria (Y2O3) nanoparticles readily react with phosphonic acids to give phosphonate-bonded yttria particles. Through the choice of phosphonic acid, the hydrophilic...