in this paper, a general introduction is given, presenting the overactive bladder syndrome (oab) and its impact on the quality of life and economical burden in patients affected. moreover, the anatomy, physiology and histology of the lower urinary tract are discussed, followed by a brief overview on the possible role of prostaglandin (pg) and phosphodiesterase type 5 (pde5) in the urinary bladd...

objective: e1a oncoprotein of adenovirus type 5 is a regulatory factor which controls transcription of other adenovirus genes. this protein promotes both viral genom replication and host cell transformation by altering the function of certain important cellular proteins such as p21 and rb. the aim of the present study was to constantly reduce the expression of e1a gene in hek 293 cell line by r...