Herpes simplex virus (HSV) entry is associated with Akt translocation to the outer leaflet of the plasma membrane to promote a complex signaling cascade. We hypothesized that phospholipid scramblase-1 (PLSCR1), a calcium responsive enzyme that flips phosphatidylserines between membrane leaflets, might redistribute Akt to the outside during entry. Confocal imaging, biotinylation of membrane prot...

apoptosis, or active cell death, is a specific mode of cell death, which is characterized by morphological changes such as chromatin condensation, fragmentation of the nucleus, cytoplasmic retraction and appearance of apoptotic bodies' containing apparently intact organelles. apoptosis occurs in physiological conditions as a regulatory mechanism of tissue growth, where cell proliferation is bal...

Phospholipids are the main component of naturally occurring bilayers. These phospholipids include phosphatidylcholines (PC), phosphatidylethanolamines (PE) and phosphatidylserines (PS) [1]. The key common feature that bilayer-forming compounds share is their amphiphilicity ie., they have defined polar and non-polar regions. This is the reason the non-polar regions orientate themselves towards t...

The nuclear magnetic resonance spectra of phosphatidylethanolamines, phosphatidylcholines, phosphatidylserines, and sphingomyelin are discussed in terms of molecular structure. The factors influencing the band width of the protons of the polar head of phosphatidylcholines are surveyed. It is found that the band widths vary with solvent and that this variation can perhaps be correlated with the ...

The monolayer properties and thermal behavior of different phosphatidylserines are presented. At neutral pH and 22 degrees C, saturated phosphatidylserines form condensed monolayers while unsaturated phosphatidylserines form liquid-expanded films. Under similar conditions, dimyristoylphosphatidylserine undergoes a transition from the liquid-expanded to the condensed state. At pH 4 and 22 degree...

The goal of this study is two folds: to conduct a literature review the beneficial use phosphatidylserine in Parkinson’s Disease (PD) and determine knowledge base opinion pharmacy students. search that was conducted revealed there are only very few clinical studies found show effect PD. students’ survey among 42 first-year professional gain insight into if they had supplement data analyzed usin...

Renal ischemia/reperfusion injury (IRI) frequently complicates shock, renal transplantation and cardiac and aortic surgery, and has prognostic significance. The translocation of phosphatidylserines to cell surfaces is an important pro-inflammatory signal for cell-stress after IRI. We hypothesized that shielding of exposed phosphatidylserines by the annexin A5 (ANXA5) homodimer Diannexin protect...

Cell-penetrating peptides (CPPs) such as HIV's trans-activating transcriptional activator (TAT) and polyarginine rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction. They may be medically useful when fused to well-chosen chains of fewer than about 35 amino acids. The author offers a simple model of transduction in which phosphatidylserines an...

The lipid composition of the human lens is distinct from most other tissues in that it is high in dihydrosphingomyelin and the most abundant glycerophospholipids in the lens are unusual 1-O-alkyl-ether linked phosphatidylethanolamines and phosphatidylserines. In this study, desorption electrospray ionization (DESI) mass spectrometry-imaging was used to determine the distribution of these lipids...