Background: The aim of the study was to investigate the hypoglycemic effects of Phloridzin. Methods and Materials: High fat diet induced diabetic KKAy mice were administered with phloridzin at an oral dose (60 mg/kg/day, ig.) for 10 weeks. A range of parameters, including blood glucose and lipid, serum insulin, glucose tolerance, were tested to evaluate its anti-hyperglycemic effects. Results: ...

When we studied the effects of polyphenols from apple fruits on melanogenesis in B16 mouse melanoma cell lines, phloridzin had dose-dependent progressive effects on melanogenesis between 10 and 500 micrograms/ml without inhibiting cell growth. At a concentration of 500 micrograms/ml, phloridzin increased the melanin content in the cells to 181% of that in control cells. In contrast, phloretin, ...

Phloridzin (phlorizin or phloretin 2'-O-glucoside) is known for blocking intestinal glucose absorption. We have investigated the anticarcinogenic effect of phloridzin and its novel derivatives using human cancer cell lines. We have synthesised novel acylated derivatives of phloridzin with six different long chain fatty acids by regioselective enzymatic acylation using Candida Antarctica lipase ...

Recent studies have shown that phloridzin, an inhibitor of sodium-glucose cotransporter (SGLT), strongly decreases high K+-induced contraction in phasic muscle, such as tenia coli, but slightly affects tonic muscle, such as trachea . In this study, we examined the inhibitory mechanism of phloridzin on high K+-induced muscle contraction in rat ileum, a phasic muscle. Phloridzin inhibited the hig...

Phloridzin is relatively abundant in species of genus Malus Miller, of which China is the most important origin and diversification center. In this study, phloridzin contents in fruits and leaves of six wild Malus species were analyzed using a RP-HPLC system. The phloridzin content varied significantly among species. The highest phloridzin content in fruits was found in M. xiaojinensis (0.63 mg...

When we studied the effects of polyphenols froin apple fruits on melanogenesis in Bl6 mouse melanoma eell lines, phloridzin had dose-dependent progressive effects on melanogenesis between 10 and 500"g/ml without inhibiting cell grewth. At a concentration of 500pg/ml, phloridzin increased the melanin content in the cells to 181Y, of that in control cells. In contrast, phloretin, the aglycon gf p...

Recently, we established that hypothalamo-pituitary-adrenal (HPA) and counterregulatory responses to insulin-induced hypoglycemia were impaired in uncontrolled streptozotocin (STZ)-diabetic (65 mg/kg) rats and insulin treatment restored most of these responses. In the current study, we used phloridzin to determine whether the restoration of blood glucose alone was sufficient to normalize HPA fu...

The metabolic fate of three flavonoids, hesperidin, eriodictyol and diosmin, isolated from citrus fruits was reported recently by Booth, Jones, and DeEds (2). A fourth flavonoid, naringin, which can be isolated readily from grapefruit, was also investigated as a potential precursor of metabolites in the urine of the rat and human. Because phloridzin is similar to naringin in structure, the form...

Purpose: To improve the aqueous solubility of phloridzin by complexing it with hydroxypropyl-βcyclodextrin (HP-β-CD). Methods: The complex of phloridzin with HP-β-CD was prepared by freeze-drying method. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), differential scanning calorimetry (DSC) and x-ray diffracto...