In humans, the administration of phencyclidine causes schizophrenic-like symptoms that persist for several weeks after withdrawal from phencyclidine use. We demonstrated here that mice pretreated with phencyclidine (10 mg/kg/day s.c. for 14 days) showed an enduring impairment of associative in a Pavlovian fear conditioning 8 days after cessation of phencyclidine treatment. Extracellular signali...

Both acute and chronic administration of N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine and dizocilpine have been proposed to mimic some of the symptoms of schizophrenia. The purposes of the present study were first, to characterize the long-term behavioral and neurodegenerative effects of subchronic administration of phencyclidine to perinatal rats and second, to determ...

Phencyclidine (also known as PCP, angel dust, crystal and hog) has become an important drug of abuse and approximately 100 cases of serious intoxication are seen each month in the Emergency Room of our hospital. Major complications reported with phencyclidine abuse include respiratory depression, convulsions, coma, rhabdomyolysis, hyperpyrexia, and hypertensive crisis (Peterson and Stillman, 19...

Phencyclidine [PCP, Sernyl#{174}, 1-(1-phencyclohexyl) piperidine] is a potent analgesic originally developed as an intravenous anesthetic. Deemed unsuitable for human use, it is currently marketed legitimately as a primate tranquilizer. The illegitimate use of phencyclidine has increased drastically throughout the United States since its “discovery” on the West Coast by the so-called drug cult...

Although it is commonly stated that phencyclidine is an antagonist at ionotropic glutamate receptors, there has been little measure of its potency on other receptors in brain tissue. Although we previously reported that phencyclidine stimulated cloned-dopamine D2Long and D2Short receptors, others reported that phencyclidine did not stimulate D2 receptors in homogenates of rat brain striatum. Th...

Introduction Zebrafish ( Danio rerio ) has evolved over the years as a preferred organism due to its vast repertoire in research fields that mimic targeted phenotype, particularly behavioral typologies and specific attributes comparable murine models relatively high homology with humans. Considering this consideration, different pharmacological treatments have been tested proven under concentra...

Accumulating evidence suggests that dysregulation of histone modification is involved in the pathogenesis and/or pathophysiology of psychiatric disorders. However, the abnormalities in histone modification in the animal model of schizophrenia and the efficacy of antipsychotics for such abnormalities remain unclear. Here, we investigated the involvement of histone modification in phencyclidine-i...

Chronic administration of a psychomotor stimulant has been shown to produce progressively enhanced effects, a phenomenon called "reverse tolerance" or sensitization. The present study reexamined the effects of the daily injection of phencyclidine on locomotor activity and stereotypy in rats, and investigated whether drug-environment conditioning was necessary for the development of behavioral s...

Preclinical Research N-methyl-D-aspartate (NMDA) receptor antagonists, such as ketamine, have emerged as novel candidate treatments for major depressive disorder, but abuse potential of these agents is a concern. The NMDA antagonist phencyclidine has known abuse liability but undefined efficacy as an antidepressant. To further evaluate the relationship between antidepressant-like and abuse-rela...