Kennedy D Nyongbela, Alain M Lannang, Godfred A Ayimele, Moses N Ngemenya, Quentin Bickle, Simon Efange Pharmacochemistry Research Group, Department of Chemistry, University of Buea, P. O. Box 63, Buea, Cameroon Department of Chemistry, Higher Teachers’ Training College, University of Maroua, P. O. Box 55, Maroua, Cameroon Department of Biochemistry and Molecular Biology, University of Buea, P....

Three phenylpropenoyl sucroses--sibiricose A5, A6 and 3',6-disinapoyl sucrose--were isolated from the 30% EtOH extract of Polygala tenuifolia, which displayed antidepressant-like action. HPLC analysis indicated that the three phenylpropenoyl sucroses could be absorbed into serum. From the serum pharmacochemistry point of view, these three phenylpropenoyl sucroses might prevent or relieve depres...

Biostructural Research, Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark (P.V., L.O., F.S.J.); Leiden-Amsterdam Center for Drug Research, Section of Molecular Toxicology, Department of Chemistry and Pharmacochemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands (P.V.,...

Within the framework of our attempts to synthesize pleiotropic anti-inflammatory agents, we have synthesized some chalcones and their corresponding 3,4-pyrrolyl derivatives. Chalcones constitute a class of compounds with high biological impact. They are known for a number of biological activities, including anti-inflammatory and free radical scavenging activities. They inhibit several enzymes i...

The purpose of this study was to study the serum pharmacochemistry of SFD as well as the material basis through analyzing the constituents absorbed in blood. The SFD was orally administrated to Wistar rats at 20 g·kg(-1), and Ultra Performance Liquid Chromatography (UPLC) fingerprints of SFD were created. Serum samples were collected for analysis, and further data processing used MarkerLynx XS ...

Ligand efficiency as a guide in fragment hit selection and optimization Sabine Schultes, Chris de Graaf, Eric E.J. Haaksma*, Iwan J.P. de Esch, Rob Leurs, Oliver Krämer Boehringer Ingelheim RCV GmbH & Co. KG, Department of Medicinal Chemistry, Dr. Boehringer-Gasse 5-11, Vienna, Austria Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal Chemistry, Department of Pharmacochem...

Traditional natural product discovery affords no information about compound structure or pharmacological activities until late in the discovery process, and leads to low probabilities of finding compounds with unique biological properties. By integrating serum pharmacochemistry-based screening with high-resolution metabolomics analysis, we have developed a new platform, termed chinmedomics whic...