Nowadays the most difficult problem in treatment of bacterial infections is the appearance of resistant bacteria to the antimicrobial agents so that the attention is being drawn to other potential targets. In view of the positive findings of phage therapy, many advantages have been mentioned which utilizes phage therapy over chemotherapy and it seems to be a promising agent to replace the antib...

nowadays the most difficult problem in treatment of bacterial infections is the appearance of resistant bacteria to the antimicrobial agents so that the attention is being drawn to other potential targets. in view of the positive findings of phage therapy, many advantages have been mentioned which utilizes phage therapy over chemotherapy and it seems to be a promising agent to replace the antib...

Objective(s): Phage therapy is a potential alternative treatment for infections caused by Acinetobacter baumannii, a significant nosocomial pathogen, which has evolved resistance to almost all conventional antimicrobial drugs in poor hygiene and conflicts areas such as Iraq. Materials and Methods: Bacteriophages were isolated to highly resistant isolates of A. baumannii to form therapeutic phag...

Intracellular pathogens reside in specialised compartments within the host cells restricting access of antibiotics. Insufficient intracellular delivery antibiotics along with several other resistance mechanisms weaken efficacy current therapies. An alternative to antibiotic therapy could be bacteriophage (phage) therapy. Although phage has been practice for a century against various bacterial i...

Streptococcus mutans is a key bacterium in dental caries, one of the most prevalent chronic infectious diseases. Conventional treatment fails to specifically target pathogenic bacteria, while tending eradicate commensal bacteria. Thus, caries remains common and challenging Phage therapy, which involves use bacterial viruses as anti-bacterial agents, has been gaining interest worldwide. Neverthe...

Background and Objective: Phage therapy could be used as an alternative method to antibiotic treatments. The purpose of this study was to evaluate the antibacterial activities of isolated lytic bacteriophage against ciprofloxacin-resistant strain of Salmonella infanits in vitro conditions. Materials and Methods: The standard strain of Salmonella infantis  and its specific bacteriophage was iso...

We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii established that the bacterial capsule is receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible biosynthesis, resulting loss disruption phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam an...

The deeply intertwined evolutionary history between bacteriophages and bacteria has endowed phages with highly specific mechanisms to hijack bacterial cell metabolism for their propagation. Here, we present a comprehensive, phage-driven strategy reveal novel antibacterial targets by the exploitation of phage-bacteria interactions. This will enable design small molecules, which mimic inhibitory ...