نتایج جستجو برای: phage therapy

تعداد نتایج: 671460  

Nowadays the most difficult problem in treatment of bacterial infections is the appearance of resistant bacteria to the antimicrobial agents so that the attention is being drawn to other potential targets. In view of the positive findings of phage therapy, many advantages have been mentioned which utilizes phage therapy over chemotherapy and it seems to be a promising agent to replace the antib...

Journal: :iranian journal of basic medical sciences 0
masoud sabouri ghannad department of microbiology, school of medicine, hamadan university of medical sciences, hamadan, iran avid mohammadi department of microbiology, school of medicine, hamadan university of medical sciences, hamadan, iran

nowadays the most difficult problem in treatment of bacterial infections is the appearance of resistant bacteria to the antimicrobial agents so that the attention is being drawn to other potential targets. in view of the positive findings of phage therapy, many advantages have been mentioned which utilizes phage therapy over chemotherapy and it seems to be a promising agent to replace the antib...

Background and purpose: Infections caused by multidrug-resistant gram-negative bacteria are rising. Phage therapy is an effective treatment in infections resistant to treatment and progress has been made with its use and development in recent years. Phage therapy in treatment of gram-negative bacterial infections is not well investigated in clinical trials. Therefore, the aim of this study was ...

Objective(s): Phage therapy is a potential alternative treatment for infections caused by Acinetobacter baumannii, a significant nosocomial pathogen, which has evolved resistance to almost all conventional antimicrobial drugs in poor hygiene and conflicts areas such as Iraq. Materials and Methods: Bacteriophages were isolated to highly resistant isolates of A. baumannii to form therapeutic phag...

Journal: :Critical Reviews in Microbiology 2021

Intracellular pathogens reside in specialised compartments within the host cells restricting access of antibiotics. Insufficient intracellular delivery antibiotics along with several other resistance mechanisms weaken efficacy current therapies. An alternative to antibiotic therapy could be bacteriophage (phage) therapy. Although phage has been practice for a century against various bacterial i...

Journal: :Canadian Young Scientist Journal 2014

Journal: :Viruses 2021

Streptococcus mutans is a key bacterium in dental caries, one of the most prevalent chronic infectious diseases. Conventional treatment fails to specifically target pathogenic bacteria, while tending eradicate commensal bacteria. Thus, caries remains common and challenging Phage therapy, which involves use bacterial viruses as anti-bacterial agents, has been gaining interest worldwide. Neverthe...

Background and Objective: Phage therapy could be used as an alternative method to antibiotic treatments. The purpose of this study was to evaluate the antibacterial activities of isolated lytic bacteriophage against ciprofloxacin-resistant strain of Salmonella infanits in vitro conditions. Materials and Methods: The standard strain of Salmonella infantis  and its specific bacteriophage was iso...

Journal: :Nature microbiology 2021

We characterized two bacteriophages, ΦFG02 and ΦCO01, against clinical isolates of Acinetobacter baumannii established that the bacterial capsule is receptor for these phages. Phage-resistant mutants harboured loss-of-function mutations in genes responsible biosynthesis, resulting loss disruption phage adsorption. The phage-resistant strains were resensitized to human complement, beta-lactam an...

Journal: :Current Opinion in Biotechnology 2021

The deeply intertwined evolutionary history between bacteriophages and bacteria has endowed phages with highly specific mechanisms to hijack bacterial cell metabolism for their propagation. Here, we present a comprehensive, phage-driven strategy reveal novel antibacterial targets by the exploitation of phage-bacteria interactions. This will enable design small molecules, which mimic inhibitory ...

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