نتایج جستجو برای: ph sensitive nanoparticles

تعداد نتایج: 539402  

2013
Hwan Kang Young - IL Jeong

pH-sensitive drug targeting using nanoparticles for cancer chemotherapy have been spotlighted in recent decades. Graft copolymer composed of poly (L-histidine) (PHS) and dextran (DexPHS) was synthesized and pH-sensitive nanoparticles were fabricated for pH-responsive drug delivery of doxorubicin (DOX). Nanoparticles of DexPHS showed pH-sensitive changes in particle sizes and drug release behavi...

2015
Muhammad Naeem Jiafu Cao Moonjeong Choi Woo Seong Kim Hyung Ryong Moon Bok Luel Lee Min-Soo Kim Yunjin Jung Jin-Wook Yoo

Current colon-targeted drug-delivery approaches for colitis therapy often utilize single pH-triggered systems, which are less reliable due to the variation of gut pH in individuals and in disease conditions. Herein, we prepared budesonide-loaded dual-sensitive nanoparticles using enzyme-sensitive azo-polyurethane and pH-sensitive methacrylate copolymer for the treatment of colitis. The therapeu...

Journal: :Colloids and surfaces. B, Biointerfaces 2014
Muhammad Naeem Wooseong Kim Jiafu Cao Yunjin Jung Jin-Wook Yoo

Novel nanoparticles whose drug release profiles are controlled by both enzyme and pH were prepared for the colon-specific drug delivery using a polymeric mixture of enzyme-sensitive azo-polyurethane and pH-sensitive Eudragit S100 (ES-Azo.pu). The enzyme/pH dual sensitive nanoparticles were designed to release a drug based on a two-fold approach which specifically aimed to target drug delivery t...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تبریز - دانشکده شیمی 1392

in the present work, a simple and sensitive method was developed for determination of morphine and heroin using gold nanoparticles as resonance rayleigh scattering (rrs) and colorimetric technique’s probe. synthesized gold nanoparticles by sodium citrate reduction method have a negative charge layer on their surfaces because of self-assembled citrate anions on their surface. binding of morphin...

2013
Jong-ho Hwang Cheol Woong Choi Hyung-Wook Kim Do Hyung Kim Tae Won Kwak Hye Myeong Lee Cy hyun Kim Chung Wook Chung Young-II Jeong Dae Hwan Kang

PURPOSE Nanoparticles based on stimuli-sensitive drug delivery have been extensively investigated for tumor targeting. Among them, pH-responsive drug targeting using pH-sensitive polymers has attracted attention because solid tumors have an acidic environment. A dextran-b-poly(L-histidine) (DexPHS) copolymer was synthesized and pH-responsive nanoparticles were fabricated for drug targeting. M...

Journal: :iranian journal of pharmaceutical research 0
naga sravan kumar varma vegesna jss college of pharmacy, jss university, mysore shivakumar h.g jss univesity balamuralidhara [email protected] jss university navya m jss university umme hani jss university

the aim of the research work was to chemically modify guar gum(gg) as a ph sensitive co-polymer and formulating intestinal targeting eso nanoparticles (nps) using the synthesized co-polymer. poly acrylamide-grafted-guar gum (paam-g-gg) co-polymer was synthesized by free radical polymerization. chemical modification of paam-g-gg by alkaline hydrolysis results in formation of a ph-sensitive co-po...

2013
Hong-ming Ding Yu-qiang Ma

The major challenge in cancer therapy is to efficiently translocate drug molecules into cancer tumors without doing any damage to healthy tissues. Since there exist pH gradients between tumor and normal tissues, pH-sensitive materials may have great potential to overcome such challenge. Here, we report one new type of pH-responsive drug delivery system where pH-sensitive polymers are introduced...

Journal: :iranian journal of basic medical sciences 0
elham khodaverdi department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran omid rajabi department of medicinal chemistry, school of pharmacy, mashhad university of medical sciences, mashhad, iran mohammad abdekhodai department of pharmaceutics, school of chemical engineering, sharif university, tehran, iran xiao yu wu department of pharmaceutics, school of pharmacy, university of toronto, toronto, canada

objective(s) in this study, a kind of ph sensitive composite membrane was prepared and drug permeation through it was investigated in terms of ph. rationale of this study originated from the fact that a ph change which may be a result of a disease state in the body can trigger drug release. materials and methods  here, a kind of ph sensitive composite membrane containing different nanoparticle ...

Journal: :Biomaterials 2008
Jin-Oh You Debra T Auguste

pH-Sensitive poly(N,N-dimethylaminoethyl methacrylate (DMAEMA)/2-hydroxyethyl methacrylate (HEMA)) nanoparticles were prepared for the triggered release of paclitaxel within a tumor microenvironment. Tumors exhibit a lower extracellular pH than normal tissues. We show that paclitaxel release from DMAEMA/HEMA particles can be actively triggered by small, physiological changes in pH (within 0.2-0...

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