Prefoldin is a molecular chaperone found in the domains eukarya and archaea that acts in conjunction with Group II chaperonin to correctly fold other nascent proteins. Previously, our group identified a putative single subunit of prefoldin, gamma PFD, that was up-regulated in response to heat stress in the hyperthermophilic archaeon Methanocaldococcus jannaschii. In order to characterize this p...

OBJECTIVE Although life vest use is thought to prevent drowning, their use by boaters has not been described. This study sought to determine the use of personal flotation devices (PFDs) in small boats. METHODS Boaters were observed between April and June 1995 in Washington and Oregon and classified by their age, gender, PFD use, and boat type. RESULTS Among 4181 boaters, 25% wore a PFD. Use...

Pirfenidone (PFD) is a newly developed anti-fibrotic agent. We evaluated the effect of PFD for the prevention of renal fibrosis using a spontaneous progressive glomerulosclerosis animal model, FGS/Kist mice. Male and female FGS/Kist mice were fed a diet containing 0.5% PFD or the same control diet (CD) without PFD, for 1, 2, or 3-month periods. Body weight was monitored for the general effect o...

Suspension cultures of Arnebia euchroma supported with liquid perfluorodecalin (PFD) degassed, aerated, or ethylene-saturated were investigated as a novel in situ extraction system for enhanced alkannin/shikonin production. Simultaneously, the effect of PFD applied as the liquid gas carrier on the growth of A. euchroma biomass was studied. The similar dry (4-fold) and fresh (7-fold) biomass inc...

The response of photosynthesis to an increase in photon flux density (PFD) from low to higher PFD was investigated using spinach (Spinacia oleracea L.). The time-course for this response was qualitatively similar to that observed for a dark-to-high-PFD transition, showing an initial, rapid increase in photosynthesis over the first minute or so, followed by a slower increase lasting 5 to 10 minu...

Although several interventions slow the progression of diabetic nephropathy, current therapies do not halt progression completely. Recent preclinical studies suggested that pirfenidone (PFD) prevents fibrosis in various diseases, but the mechanisms underlying its antifibrotic action are incompletely understood. Here, we evaluated the role of PFD in regulation of the extracellular matrix. In mou...

In this paper, we introduce a high-speed and low-power Phase-Frequency Detector (PFD) that is designed using a modified TSPC (True Single-Phase Clock) positive edge triggered D flip-flop . The proposed PFD has a simple structure with using only 19 transistors. The operation range of this PFD is over 1.4GHz without using additional prescaler circuits. Furthermore, the PFD has a dead zone less th...

OBJECTIVE To assess the usefulness of pulsatile flow detection (PFD), a newly developed function of color Doppler US, in measuring resistive index (RI) in renal Doppler US and to compare it with conventional color Doppler (CCD). MATERIALS AND METHODS Fifty-six kidneys in 31 patients were randomly selected and divided into two groups. In group A, RI was measured first with the aid of CCD, and ...

This paper introduces a new-type Phase-Frequency Detector (PFD) for Charge-Pump based Phase-Looked-loops (CPPLLs). Dead zone in a phase-frequency detector reduces the input detection range and make worse cycle slips. This brief analyzes the blind zone in latch-based PFDs and proposes a technique that removes the blind zone caused by the pre-charge time of the internal nodes. With the proposed t...

The potential role of PFD [5-methyl-L-phenyl-2-(1H)-pyridone], an antifibrotic compound with anti-inflammatory effects, in several models of acute lung injury (ALI) has gained increasing attention; however, the protective effect of PFD in oleic acid (OA)-induced ALI remains unknown. We hypothesized that PFD protects from OA-induced ALI in rats, and we hoped to obtain the optimum preclinical con...