cor triatriatum is an acyanotic congenital heart disease. we present a rare case of cor triatriatum sinistrum in a 6-month-old female infant who was presented with cyanosis and failure to thrive. the 2d transthoracic echocardiography and the doppler color flow imaging showed a proximal venous chamber communicating to the distal left atrium  through restrictive opening to the low-pressure, dista...

Neonates with pulmonary atresia and intact interventricular septum (PAIVS) do not have pulmonary vascular disease secondary to their heart abnormality. Persistent pulmonary hypertension of the newborn has not been described in association with this condition. The case is reported of a female neonate born with PAIVS, who preoperatively had no clinical evidence or any risk factors for persistent ...

the purpose of this investigation was to assess the effect of captopril on both systemic (p.a) and pulmonary arterial pressures (ppa) in patients with high-altitude pulmonary hypertension (haph). seventeen patients (mean age 44±6.8 years) with haph and mild to moderate systemic arterial hypertension were included in the study. all patients underwent right heart catheterization with measurements...

Neonates with pulmonary atresia and intact interventricular septum (PAIVS) do not have pulmonary vascular disease secondary to their heart abnormality. Persistent pulmonary hypertension of the newborn has not been described in association with this condition. The case is reported of a female neonate born with PAIVS, who preoperatively had no clinical evidence or any risk factors for persistent ...

Endogenous formation of thromboxane A2 and prostacyclin were evaluated in seven neonatates with persistent pulmonary hypertension by serial gas chromatographic mass spectrometric determination of their urinary metabolites dinor-thromboxane B2 and dinor-6-keto-prostaglandin F1 alpha, respectively. The patients were studied until their hypertension had resolved on clinical criteria. Urinary excre...

BACKGROUND Persistent pulmonary hypertension is a well-known disease of the newborn that in most cases responds well to treatment with nitric oxide and treatment of any underlying causes. Genetic causes of persistent pulmonary hypertension of the newborn are rare. The TWIST1 gene is involved in morphogenetics, and deletions are known to cause Saethre-Chotzen syndrome. Deletions of PHF14 have ne...

conclusions we observed acceptable results regarding both efficacy and safety with 62.5 mg of bosentan, twice daily in this group of patients. further clinical trials investigating pah with lower dosages of bosentan may be warranted. results no adverse drug reaction was observed during the follow-up. clinical worsening occurred in six (14%) patients, at least one year after treatment, two of th...

OBJECTIVE To examine the risk for persistent pulmonary hypertension of the newborn associated with antenatal exposure to antidepressants. DESIGN Systematic review and meta-analysis. DATA SOURCES Embase, Medline, PsycINFO, and CINAHL from inception to 30 December 2012. ELIGIBILITY English language studies reporting persistent pulmonary hypertension of the newborn associated with exposure t...