نتایج جستجو برای: permeation enhancer

تعداد نتایج: 29062  

Journal: :research in pharmaceutical sciences 0

the purpose of this work was to study the effect of various permeation enhancers on the permeation of salbutamol sulphate (ss) buccal patches through buccal mucosa in order to improve the bioavailability by avoiding the first pass metabolism in the liver and possibly in the gut wall and also achieve a better therapeutic effect. the influence of various permeation enhancers, such as dimethyl sul...

Journal: :iranian journal of pharmaceutical research 0
n noorani afshin zarghi

many properties of chemicals depend on their stereochemistry. among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. we have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. as, depending on their lipophilicity, penetration enhancers can change ...

Journal: :iranian journal of pharmaceutical sciences 0
pavani sriram 2-2-28/3,bus stand road mahabubabad madusudhan rao yamsani director, vaagdevi group of pharmacy colleges, warangal yamsani shravan kumar department of pharmaceutics, vaagdevi college of pharmacy, india

the aim of the present study was to develop and investigate the feasibility of delivering nebivolol as a transdermal patch by iontophoresis. the passive and electrically assisted transdermal delivery of nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. because of its extensive hepatic metabolism and low dos...

Journal: :iranian journal of basic medical sciences 0
soliman mohammadi-samani department of pharmaceutics, school of pharmacy, shiraz university of medical sciences, shiraz, iran center for nanotechnology in drug delivery, shiraz university of medical sciences, shiraz, iran gholamhossein yousefi department of pharmaceutics, school of pharmacy, shiraz university of medical sciences, shiraz, iran center for nanotechnology in drug delivery, shiraz university of medical sciences, shiraz, iran farhad mohammadi department of pharmaceutics, school of pharmacy, shiraz university of medical sciences, shiraz, iran fatemeh ahmadi department of pharmaceutics, school of pharmacy, shiraz university of medical sciences, shiraz, iran center for nanotechnology in drug delivery, shiraz university of medical sciences, shiraz, iran

objective(s):drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. analgesics such as nsaids have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. meloxicam is one of nsaids with no topical form in the market. in this research, we attempted to quantify the skin permeation of a m...

Objective(s):Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a m...

Afshin Zarghi, HR Moghimi N Noorani

Many properties of chemicals depend on their stereochemistry. Among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. We have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. As, depending on their lipophilicity, penetration enhancers can change ...

Afshin Zarghi, HR Moghimi N Noorani

Many properties of chemicals depend on their stereochemistry. Among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. We have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. As, depending on their lipophilicity, penetration enhancers can change ...

Asal Mirmohammad Sadeghi Mohammad Reza Avadi Morvarid Goharzadeh Orkide Ghorban Dadras Zahra Ghassemi

In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan and its derivatives have been studied as permeation enhancer. The aim of the current study was to develop a nanoparticulate system based on ...

Assal Mir Mohammad Sadeghi Mohammad Reza Avadi Morvarid Goharzadeh Orkide Ghorban Dadras

In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan derivatives have been studied as permeation enhancer in free soluble form and as nanoparticulate systems. The aim of the current work wa...

2017
Venkateswara Rao

Transdermal route offers inherent advantages over other conventional routes for the delivery of drugs with systemic activity. Transdermal drug delivery provides a continuous mode of administration at rates approaching zero-order similar to that provided by an intravenous infusion.The greatest obstacle is the stratum corneum, the outermost layer of the skin, which is considered to form a primary...

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