The existence and distribution of melanocytes in the periodontal ligament of the mongrel dog were investigated. Melanocytes were found in the periodontal ligament of the maxillary incisor and premolar segments. Melanocytes in the periodontal ligament varied in number, and generally appeared as dendritic or elongated cells with several, long cytoplasmic processes. These melanocytes were always d...

The aim of this study was to investigate whether a new periodontal ligament attachment will form on titanium implants when they are implanted with cultured periodontal ligament cells. Periodontal ligament cells obtained from the teeth of 3 dogs were cultured and attached to the surface of titanium implants. The implants with the cultured autologous periodontal ligament cells were placed in the ...

avulsion is one of the most serious emergencies in dental office. in the event of any problem, the tooth should be stored in a medium that supports the periodontal ligament cell viability. in other clinical situations, preserving media, growth factors and mitogenic products may be useful in repairing the traumatized tissues. it has been previously reported that levodopa (l-dopa) accelerates hea...

background: periodontal ligament stem cells (pdlscs) are considered as a type of mesenchymal stem cell that is beneficial target for numerous clinical applications in periodontal tissue regeneration therapy. materials and methods: this study examined the effects of dexamethasone (dex) on human pdlscs in vitro. pdlscs obtained from the roots of patient’s teeth were cultured with dex (0.01 μm), a...

Both periodontal ligament and gingival tissue are thought to harbor cells with the ability to stimulate periodontal regeneration, i.e., formation of new bone, cementum, and connective tissue attachment. To understand further the role of these cells in the regenerative process, we compared human periodontal ligament cells and gingival fibroblasts, both derived from the same patient, same passage...

PURPOSE The aim of this article is to review a group of lesions associated with periodontal ligament (PDL) widening. MATERIALS AND METHODS An electronic search was performed using specialized databases such as Google Scholar, PubMed, PubMed Central, Science Direct, and Scopus to find relevant studies by using keywords such as "periodontium", "periodontal ligament", "periodontal ligament space...

Orthodontic forces are capable of reorganizing and remodeling the periodontal ligament, to facilitate tooth movement. Optimal forces will produce favorable tissue responses, but whenever this balance is lost (as in the case of high force magnitudes, or in the presence of reduced periodontal support), the periodontal ligament may respond differently. This review highlights the responses of the p...

BACKGROUND We previously demonstrated that 25-hydroxyvitamin D(3) concentrations in gingival crevicular fluid are 300 times higher than those in the plasma of patients with aggressive periodontitis. Here we explored whether 25-hydroxyvitamin D(3) can be synthesized by periodontal soft tissue cells. We also investigated which of the two main kinds of hydroxylases, CYP27A1 and CYP2R1, is the key ...

The Hertwig’s epithelial root sheath is a transient structure formed in the early period of root formation. It has an important role in regulation and maintenance of the periodontal ligament space, prevention of root resorption and ankylosis, maintenance of periodontal ligament homeostasis, Induction of acellular cementum formation, as a stem cell in periodontal regeneration and also as a stimu...

We here report the development of two peptide scaffolds designed for periodontal ligament fibroblasts. The scaffolds consist of one of the pure self-assembling peptide scaffolds RADA16 through direct coupling to short biologically active motifs. The motifs are 2-unit RGD binding sequence PRG (PRGDSGYRGDS) and laminin cell adhesion motif PDS (PDSGR). RGD and laminin have been previously shown to...