background tracking various biomarkers in serum, gingival crevicular fluid (gcf), and saliva has been introduced as a diagnostic tool for periodontal disease detection. objectives the aim of this study was to compare salivary lactate dehydrogenase (ldh) levels in subjects with periodontal disease and levels in subjects without periodontal disease. conclusions salivary ldh levels can be used as ...

background: the purpose of this study was to determine the salivary levels of alkaline phosphatase (alp) and acid phosphatase (acp) activities in patients with periodontal disease and to evaluate the use of these enzymes as biochemical markers for periodontal tissue damage. materials and methods: in this prospective analytical study, we examined the activities of salivary alp and acp in patient...

The purpose of this article is to review available literature on proteomics in healthy and diseased periodontal structures. The proteins are the building blocks for both microorganisms and periodontium. Periodontitis is the result of complex interrelationship between infectious agents and host factors. The onset, progression and severity of periodontal disease are mainly mediated by various pro...

The current clinical diagnostic criteria were introduced almost a half century ago continue to use as the basic of oral diagnosis in today’s clinical practice. But the disadvantages are they measure disease severity rather than disease activity. Evolvement with time is brought us to the era of biomarkers. Biomarkers are micro molecules that can be used as to measure health status, disease onset...

BACKGROUND Periodontitis is the major cause of tooth loss in adults and is linked to systemic illnesses, such as cardiovascular disease and stroke. The development of rapid point-of-care (POC) chairside diagnostics has the potential for the early detection of periodontal infection and progression to identify incipient disease and reduce health care costs. However, validation of effective diagno...

background and aims. traditional methods of diagnosing periodontal diseases have their limitations, which include inability to provide information about the recent activity of the disease and difficulty in diagnosing the disease at an early stage when clinical changes have not started. this has necessitated the use of biomarkers designed to overcome these short-comings. materials and methods. a...

BACKGROUND It is well documented that there is some correlation between poor oral health in the form of periodontal disease and coronary heart disease (CHD). It is unclear whether this correlation is due to a causal relationship or shared underlying disorder such as inflammation. A suitable integrated model of the CHD pathogenetic pathways relevant to periodontal disease may help to elucidate t...

objective: chronic periodontitis is the most common form of periodontal disease. changes in biomarkers seem to be associated with the disease progression. procalcitonin (pct) is one of these biomarkers that are altered during infection. this study was established to investigate the relationship between periodontitis as an infectious disease and salivary pct. materials and methods: this case-con...

Periodontal diagnosis and treatment plan are based on the assessment of probing depth, clinical attachment level, plaque index, gingival index, bleeding on probing, suppuration, furcation involvement, mobility, and radiographic findings. However, these clinical parameters are not sufficiently sensitive and specific to identify disease activity in individual sites or to predict future attachment...

OBJECTIVES The article aims to discuss the IL-1β and TNF-α potential use as salivary biomarkers of periodontal diseases pathogenesis and progression. MATERIAL AND METHODS This literature review has been registered in PROSPERO database with following number: CRD42016035729. Data investigation was performed on PubMed database as the main source of studies. The following search terms were used: ...