نتایج جستجو برای: percutaneous absorption
تعداد نتایج: 187163 فیلتر نتایج به سال:
cyproterone acetate (ca) has been loaded to liposome by solvent evaporation and thin film formation technique. the effects of some formulation variables such as temperature of organic solvent evaporation, rotary evaporator speed, volume of organic solvent, volume of balloon and temperature of hydrating buffer has been evaluated. the data showed that bigger balloon with higher surface area has b...
many properties of chemicals depend on their streochemistry. among these, the effects of streoisomerism on percutaneous absorption of drugs, which is subject of the present investigation, is not well studied yet. in this study, tretinoin (tt) and isotretinoin (itt) (geometric isomers) were chosen and their permeations (alone or in the presence of each other) through enhancer-treated excised rat...
Background and purpose: Hirsutism, the growing unwanted terminal hair, is one of the disorders which affect life style. Spironolactone is one of the common drugs used in treatment of hirsutism. Topical preparation has been focused in many researches due to side effects after oral administration. In this study, the effect of formulation ingredients on spironolactone emulgel characteristics was e...
achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermatological products. the use of penetration enhancers could provide a successful mean for this purpose. the aim of this study was to evaluate the effect of incorporating a few common penetration enhancers (in different concentrations) into a 0.5% w/w piroxicam (model drug) gel formulation, on th...
The percutaneous absorption of hydrocortisone and testosterone was studied following their application to the vulvar and ventral forearm regions of pre- and post-menopausal women. Percutaneous absorption of hydrocortisone was significantly greater in vulvar skin than forearm skin in both pre- and post-menopausal women (P < 0.05, respectively), whereas the percutaneous absorption of testosterone...
Curcumin is the active component of Curcuma species including C. longa (turmeric). This molecule is well known for its anti-inflammatory effect, which seems to be stronger than that of hydrocortisone. Curcuma species have been used in Asian traditional medicine as topical anti-inflammatory drugs. Curcumin has poor oral bioavailability and its topical application could be of choice, particularly...
Curcumin is the active component of Curcuma species including C. longa (turmeric). This molecule is well known for its anti-inflammatory effect, which seems to be stronger than that of hydrocortisone. Curcuma species have been used in Asian traditional medicine as topical anti-inflammatory drugs. Curcumin has poor oral bioavailability and its topical application could be of choice, particularly...
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