نتایج جستجو برای: peptidomimetic
تعداد نتایج: 722 فیلتر نتایج به سال:
Despite the great advantages of peptidomimetic scaffolds, there are only a few examples their application in field asymmetric catalysis. Peptidomimetic scaffolds offer numerous related to easy preparation, modular and tunable structures, biomimetic features, which make them well suited as chiral catalysts. This review underlines structure–function relationship for catalytic properties towards e...
Macrocyclization between head, tail or sidechains is a frequently employed strategy to enhance peptide and peptidomimetic stability, selectivity affinity.
Antimicrobial peptides (AMPs) and synthetic analogues thereof target conserved structures of bacterial cell envelopes and hence, development of resistance has been considered an unlikely event. However, recently bacterial resistance to AMPs has been observed, and the aim of the present study was to determine whether bacterial resistance may also evolve against synthetic AMP analogues, e.g. α-pe...
Polypeptoids bearing carboxylic acid groups on the N-substituent are useful building blocks for construction of peptidomimetic supramolecular assemblies with stimuli-responsive properties.
Introduction: The COVID-19 pandemic has cast a heavy toll in human lives and global economics. is caused by the SARS-CoV-2 virus, which infects cells via its spike protein binding ACE2. Methods: To discover potential inhibitory peptidomimetic macrocycles for spike/ACE2 complex we deployed Artificial Intelligence guided virtual screening with three distinct strategies: 1) Allosteric inhibitors 2...
The ability of a peptidomimetic (SC-67655) to block the peptide binding site of the rheumatoid arthritis-linked human leukocyte antigen encoded by the DRB1*0401 allele was evaluated. The inhibitor bound to purified DRB1*0401 molecules with an affinity similar to that of the well-characterized peptide ligand HA307-319. Cell binding assays demonstrated that, in contrast to the promiscuous HA307-3...
Phage display is a powerful method for selecting peptides with novel binding functions. Synthetic peptidomimetic chemistry is a powerful tool for creating structural diversity in ligands as a means to establish structure-activity relationships. Here we illustrate a method of bridging these two methodologies, by starting with a disulfide bridged phage display peptide which binds a human antibody...
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