collagen, which is widely distributed in pluricellular animals, is one of the most fundamental constituents of the extracellular matrix, and plays mechanically or physiologically important roles in their bodies. in this study, the biochemical and physical characteristics of pepsin-solubilized collagen from the mantle of yesso scallop (ympc), a by-product of processing, was determined. electroph...

The structure of atrial natriurtic peptide (ANP) and Brain natriuretic peptide (BNP) are similar and they are also similar in their actions e.g natriuresis and vasodilation. The previous studies have revealed the presence of ANP and BNP in sheep atrial extract, wherease ANP in human atrial. The aim of the present study is to investigate the comparison of hemodynamic effects of these two atrial ...

The formulation of a broadly protective vaccine to prevent the serogroup B Neisseria meningitidis (MenB) disease is still an unmet medical need. We have previously reported the induction of bactericidal and protective antibodies against MenB after immunization of mice with a phage-displayed peptide named 4 L-5. This peptide mimics a capsular polysaccharide (CPS) epitope in MenB. With the aim of...

The structure of atrial natriurtic peptide (ANP) and Brain natriuretic peptide (BNP) are similar and they are also similar in their actions e.g natriuresis and vasodilation. The previous studies have revealed the presence of ANP and BNP in sheep atrial extract, wherease ANP in human atrial. The aim of the present study is to investigate the comparison of hemodynamic effects of these two atrial ...

Peptides, defined as sequences of amino acids up to approximately 50 residues in length, represent an extremely large reservoir potentially bioactive compounds, referred here the peptide chemical space. Recent advances computer hardware and software have led a wide application computational methods explore this Here, we review different silico approaches including structure-based design, geneti...

Multiple Ag peptides (MAPs) containing eight proteolipid protein (PLP)(139-151) peptides arranged around a dendrimeric branched lysine core were used to influence the expression and development of relapsing experimental allergic encephalomyelitis (EAE) in SJL mice. The PLP(139-151) MAPs were very efficient agents in preventing the development of clinical disease when administered after immuniza...

The critical role that antibody responses to the V3 loop epitope play in human immunodeficiency virus type 1 (HIV-1) neutralization has caused this peptide to be used in many HIV-1 vaccine candidates. To enhance cross-reactivity toward several V3 sequences, a database of 50 peptides of the V3 region from HIV-1 subtype A was used to design both a consensus peptide and a combinatorial peptide (mi...

A convenient and versatile approach to the direct synthesis of a peptide-antigen matrix by the solid-phase method is described. The approach is called the multiple antigen peptide system (MAP) and it utilizes a simple scaffolding of a low number of sequential levels (n) of a trifunctional amino acid as the core matrix and 2n peptide antigens to form a macromolecule with a high density of peptid...