abstract       background and objective: baba2 and hpa genes are involved in adherence of helicobacter pylori (h.pylori) to gastric mucosal tissue. this study aimed to investigate the frequency of these genes in isolates of h. pylori from gastric biopsies and their relationship with gastritis, peptic ulcer and gastric cancer.       methods: gastric biopsy samples were obtained from patients wit...

back ground and amis: among the patients who go to physicians, especially to gastroentero logists, a great number consists of the onse suffering upper gi diseases, particularly peptic ulcer disease (pud) which,â  in addition to creating much pain and lowering the quality of life causes a great morbidity and â mortality. so it seems necessary to be cured.â according to the lastâ  researchesâ  th...

Peptic ulcer is one of the most important and frequent gastrointestinal diseases in Japan similarly as in the foreign countries. Although the reports of statistics on peptic ulcer of pathologicanatomical and clinical materials and of mortality have been presented abundantly, there are but few which review widely the true and accurate features of peptic ulcer in Japan. Recently we had an opportu...

BACKGROUND AND AIM In our previous study, the SLCO1B1 521TT genotype and the SLCO1B1*1b haplotype were significantly associated with the risk of peptic ulcer in patients taking low-dose aspirin (LDA). The aim of the present study was to investigate pharmacogenomic profile of LDA-induced peptic ulcer and ulcer bleeding. METHODS Patients taking 100 mg of enteric-coated aspirin for cardiovascula...

Gastric biopsy specimens from 156 adult patients from southern Estonia suffering from chronic gastritis, peptic ulcer disease, and perforated peptic ulcer were analyzed by PCR. The cagA gene was evenly distributed throughout 87% of the specimens from the patients with the different gastric diseases. The presence of the cagA gene correlated with that of vacA signal sequence type s1a (99%). Howev...

An idiopathic peptic ulcer is defined as an ulcer with unknown cause or an ulcer that appears to arise spontaneously. The first step in treatment is to exclude common possible causes, including Helicobacter pylori infection, infection with other pathogens, ulcerogenic drugs, and uncommon diseases with upper gastrointestinal manifestations. When all known causes are excluded, a diagnosis of idio...

Sula, Parinamasula and Amlapitta are clinical entities recognized by ayurveda, akin to peptic ulcer and functional dyspepsia. Many indigenous drugs have been advocated in ayurveda for treatment of dyspepsia. Our laboratory has been engaged in screening of various indigenous herbal and metallic drugs for their potential use in peptic ulcer diseases, taking lead from Ayurveda and have reported an...