background: opioid peptides and their receptors are present in the majority of body tissues including gastrointestinal tract.  heroin is one of the opioid derivatives that abuse increasingly today.  so far, there is no study on the effect of acute heroin administration on gastric acid and pepsin secretion.   objective:  to define the effect of the acute heroin consumption on basal and vagal-sti...

1. Of the three major human pepsins, pepsin 1 has greater proteolytic activity towards ovalbumin than has pepsin 3. Pepsin 5 has low activity towards this substrate. 2. Proteolytic pH-activity curves show only on pH maximum, about pH 1.4 for pepsin 1, pH 1.4--1.5 for pepsin 3 and pH 1.2--1.4 for pepsin 5. The curve for pepsin 3 has a shoulder between pH 2.4 and 3.4. 3. The rate of digestion of ...

The ability to digest mucus, mucolytic activity of isolated pepsins and samples of human gastric juice has been assayed by measuring the fall in viscosity when incubated with purified pig gastric mucus glycoprotein. Pure human pepsin 1, the peptic ulcer associated pepsin, digested gastric mucus glycoprotein at a faster rate than did pure human pepsin 3 (the principal human pepsin), or the equiv...

Background: Opioid peptides and their receptors are present in the majority of body tissues including gastrointestinal tract.  Heroin is one of the opioid derivatives that abuse increasingly today.  So far, there is no study on the effect of acute heroin administration on gastric acid and pepsin secretion. Objective:  To define the effect of the acute heroin consumption on basal and vagal-stimu...

OBJECTIVES/HYPOTHESIS To assess if, as previously reported in the literature, bile acids inhibit pepsin activity, resulting in pepsin having a less important role in laryngopharyngeal damage in reflux disease. STUDY DESIGN Prospective translational research study. METHODS A total of 78 patient's fasting gastric juice samples were obtained from routine endoscopy. The total bile acid (TBA) co...

Pepstatin, a strongly bound inhibitor of acid proteases, does not instantaneously bind to pepsin. The dissociation constant of pepsin-pepstatin complex is 9.7×10-11 M using Phe・Gly・His・Phe(NO2)・Phe・Ala・PheOMe as substrate. Difference ultraviolet absorption spectra show conformational change of pepsin in interaction with pepstatin. The bindillg of pepsin with pepstatin is stoicheometric and the ...

objective(s) the liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. some studies reported a gastric acid secretion reduction in cirrhotic subjects, whi...

Objective(s) Gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. The female sex has more resistance to stress and the gastrointestinal lesions happen fewer than male sex. The purpose of this study was to evaluate the role of estradiol and progesterone on the gastric acid and pepsin levels following traumatic brain injury (TBI) induction. Materials and M...