in the present study, the effects of caerulein and cck receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for ant...

We studied the effects of desipramine, alprazolam, muscimol and dizocilpine (MK-801) (alone or associated with desipramine) in the forced swimming test in rats after long-lasting termination of chronic exposure to vehicle and pentylenetetrazol. Sensitisation with pentylenetetrazol was ineffective in changing immobility time in the forced swimming test compared to vehicle treatment; pentylenetet...

Sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. The aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. Swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. These group...

UNLABELLED The AIM was to study the effects of lamotrigine on bicuculline and pentylenetetrazol models of epilepsy. MATERIAL AND METHODS Mice divided in 8 groups (n = 6) were pretreated intraperitoneally 30 min before pentylenetetrazol (50 mg/kg) or bicuculline (1 mg/kg) with saline 0.1 ml/10 g body weight or lamotrigine 10 mg/kg, 15 mg/kg or 20 mg/kg, respectively. The seizure intensity and ...

UNLABELLED Accumulated evidence has shown that renin-angiotensin system has a pivotal role in stress responses. AIM to assess the participation of AT1 receptor in stress-induced modulation of motor activity, nociception and seizure susceptibility in male Wistar rats. MATERIAL AND METHODS AT1 receptor antagonist losartan was administered subcutaneously to rats for 10 days at a dose of 10 mg/...

Previous studies had shown that the exogenous cannabinoids can induce anticonvulsion, which was believed to be mediated through the activation of central cannabinoid Type 1 receptors. Moreover, the endogenous cannabinoid anandamide has shown anticonvulsant properties in the in vitro preparations. The current study used 27 adult Sprague-Dawley rats to investigate the effects of another endogenou...

The interaction of pentobarbitone sodium with three analeptics viz. micoren, pentylenetetrazol and methedrine was studied in mice. Micoren prolonged pentobarbitone sleeping time. pentylenetetrazol shortened the sleeping time. Methedrine also shortened the sleeping time, but clonic convulsions of mild to severe intensity were noticed 45-60 minutes after the drug injection.

objective(s): stress induces many homeostatic aberrations which are followed by lifelong allostatic responses. epilepsy is developed or influenced by different environmental factors, i.e. prenatal stress which makes many contradictory developmental changes in seizure threshold and intensity. we investigated the potential seizure response of the rat offspring to prenatal stress; the stress which...

sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. the aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. these group...