Conidia of Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Penicillium brevi-compactum, Penicillium frequentans, Penicillium spinulosum, and Penicillium verrucosum var. cyclopium were subjected to partition at varying pH values in an aqueous two-phase system containing charged polyethylene glycol. In the system, the partition behavior of the conidia of the Penicillium species vari...

mycophenolic acid is a secondary extracellular metabolite of penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. the aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by penicillium brevi-compactum atcc16024 was investigated. batch submerged fer...

Mycophenolic acid is a secondary extracellular metabolite of Penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. The aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by Penicillium brevi-compactum ATCC16024 was investigated. Batch submerged fer...

Various fractions were extracted from cell-wall material of Eupenicillium crustaceum, Penicillium brevi-compactum, P. decumbens, Aspergillus flavipes and A. ochraceus. The most characteristic fractions, which may have chemotaxonomic relevance, were F1I, an alpha-(1-3) glucan (alkalisoluble, water-insoluble), which amounted to 16.2-32.5% of the cell-wall material, and F1S (alkali and water-solub...

Mycophenolic acid is a secondary extracellular metabolite of Penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. The aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by Penicillium brevi-compactum ATCC16024 was investigated. Batch submerged fer...

Mycophenolic acid is a secondary extracellular metabolite of Penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. The aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by Penicillium brevi-compactum ATCC16024 was investigated. Batch submerged fer...

Virus particles and their component double-stranded ribonucleic acid (dsRNA) have been isolated from conidia and mycelia of certain Penicillium species. The conidia and mycelia of P. stoloniferum NRRL 5267 contained 75 and 85 mug of dsRNA/g (dry weight), respectively. Of the total dsRNA released from NRRL 5267 conidia, 10% was nonencapsulated. Conidia of P. brevi-compactum NRRL 5260 and P. chry...

DETRO)", R, \\"., S. N. FREER, and D. I. FEC;C;ELL. 1973. Relationship betwcen the biosynthesis of viruslike panic!cs and mycophenolic acid in Pellicillilllll s!olonifertlli1 and Penicillium hrel'i-compaCfIlIll. Can. J. ivlicrobiol. 19: 1459-1462. Several strains of Penieillilllll s!olonZrerll'n and P. breci-compaCI/ll1l containing no virus-like particles (YLP) synthesize mycophenolic acid (MAl...

Little is known about the relationship between mycoviruses and fungal secondary metabolism. An in vivo replication system from Penicillium stoloniferum strain NRRL 5267 has been developed to test various fungal products and other antimetabolites against P. stolonlferum fast-moving virus (PsV·f) replication. Initially, cycloheximide was investigated in this test system because of its known antif...

In a recent paper (l), we reported the formation of itatartaric acid by an ultraviolet-induced mutant of Aspergillus terreus. We have since found that by prolonged ether extraction of the concentrated culture liquor therein described a brown gum is obtained which, after some months standing, deposited large crystals. These crystals (3.25 gm.) could be separated from the gum on the basis of thei...