BACKGROUND Benzathine penicillin G every 3 weeks is the standard protocol for secondary prophylaxis for recurrent rheumatic fever. OBJECTIVE Assess the effect of Benzathine penicillin G on Streptococcus sanguinis and Streptococcus oralis in patients with cardiac valvular disease due to rheumatic fever receiving secondary prophylaxis. METHODS Oral streptococci were evaluated before (baseline...

Two patients developed neurosyphilis after treatment of latent syphilis with intramuscular benzathine penicillin. The cases confirm recent investigations that show that neither benzathine penicillin nor procaine penicillin in the standard doses results in treponemicidal concentrations of penicillin in cerebrospinal fluid. Neurosyphilis can be treated effectively by intravenous benzylpenicillin ...

A 7-year old boy developed myositis secondary to intramuscular injection of benzathine penicillin-G in the context of secondary prophylaxis for rheumatic heart disease. Side effects of intramuscular delivery of benzathine penicillin-G are well described and include injection site pain and inflammation, but myositis, as depicted on magnetic resonance imaging in this case, has not previously been...

BACKGROUND An interval of 3-4 weeks between intramuscular injections of 1.2 million units of benzathine penicillin G as prophylaxis against group A streptococcal infection is recommended by health organizations for patients with pediatric rheumatic fever and heart disease. METHODS We reviewed the literature for evidence of the persistence of serum penicillin G during the first 4 weeks after t...

The concentrations of penicillin in the cerebrospinal fluid (CSF) were compared simultaneously with those in the serum in 17 patients with syphilis. The antibiotic concentrations were measured by the agar well diffusion method. There were no detectable concentrations of penicillin in the CSF after administration of benzathine penicillin 2.4 megaunits, benzathine penicillin 7.2 megaunits, procai...

Latar belakang. Infeksi Streptococcus yang memicu demam rematik dapat mendasari terjadinya penyakit jantung didapat pada anak. Demam dicegah baik dari pencegahan primordial, primer, dan sekunder. Anak dengan keparahan penyakitnya mencegah infeksi berulang atau Pencegahan sekunder dianjurkan oleh World Health Organization (WHO) adalah pemberian Benzathine Penicillin G (BPG) setiap 3 – 4 minggu. ...

OBJECTIVE To determine the efficacy of single-dose benzathine penicillin G in infants at high risk of congenital syphilis. DESIGN Randomised study comparing benzathine penicillin with no therapy. SETTING Peninsula Maternal and Neonatal Service, Cape Town. SUBJECTS Asymptomatic infants born to mothers with untreated syphilis whose VDRL titre was 32 or more. OUTCOME MEASURES The number of...

INTRODUCTION The Jarisch-Herxheimer reaction, a febrile inflammatory reaction that often occurs after the first dose of chemotherapy in spirochetal diseases, may result in deleterious effects to patients with neurosyphilis and to pregnant women. A single 2-g oral dose of azithromycin is an alternative treatment to benzathine penicillin G for early syphilis in areas with low macrolide resistance...