background and aims. pemphigus is a chronic autoimmune and vesiculobollous disease that can affect skin and different mucous membrane surfaces. primary manifestations occur in oral cavity in almost 60% of cases. the purpose of the present study was to evaluate the epidemiology of pemphigus in tehran, iran in a 20-year period. materials and methods. a retrospective study was conducted on the rec...

background: pemphigus vulgaris is a life threatening, blistering skin disease. it is an autoimmune abnormality. due to involvement of oral cavity and pharynx, patients are at risk of nutrients deficiency. the aim of this study was to evaluate the status of selenium, copper, and zinc in these patients. methods: in a case-control study, 43 newly diagnosed pemphigus vulgaris patients were compared...

conclusions: prevalence of hsv1/2 in mucocutaneous biopsies from pemphigus patients is 2.5% and possibly hsv1/2 has no role in the pathogenesis of pemphigus lesions. but resistant cases to treatment might be suspected to hsv. results: ten patients (25%) had a history of orolabial herpes infection. the results of all samples were negative for hsv1 except one sample which showed the positive resu...

OBJECTIVES To conduct a cross-sectional study to compare Dsg1 and Dsg3 antibody levels independently with severity of disease activity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). METHODS Blood samples from 44 patients with pemphigus (PV-38, PF-6) were analyzed using ELISA. The severity of skin and mucosal disease was graded using a score from 0 to 3. RESULTS A statistically sig...

Pemphigus (from the Greek pemphix, meaning bubble or blister) is a blistering disease involving the skin and mucous membrane. The disease is characterized histologically by acantholysis which means loss of adhesion between keratinocytes, and immuno-pathologically by the presence of immunoglobulin directed towards the cell surface of kerat inocytes . 1 The landmark ar t ic le in the understandin...

Background: Pemphigus is an autoimmune disease characterized with intra-epidermal cleavage. Objective: The aim of this study was to examine the clinical and epidemiologic features of pemphigus in Khouzestan province, southwest Iran. Patients and Methods: All new cases of pemphigus admitted in the department of dermatology, Sina Hospital, Ahwaz University from October 1990 to September 1999 were...

Pemphigus vulgaris is a blistering autoimmune disease with suprabasal cleft formation, which is the most common autoimmune blistering disease in eastern countries, such as Middle East. Predisposition to pemphigus is linked to genetic factors. Tuberous sclerosis is also a genetic disorder of hamartoma formation in many organs, particularly the skin, brain, eye, kidney and heart. We report ...

background: pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes. objectives: to investigate the potential role of il-23 in pemphigus vulgaris. methods: in this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion and...

objective: pemphigus is a rare autoimmune disease that may be fatal without proper medical intervention. it is a blistering disease that involves both the skin and mucus membranes, in which the most important causes of death comprise superimposed opportunistic infections and complications of long-term high-dose corticosteroid therapy or prolonged consumption of immune suppressant drugs. skin le...

Paraneoplastic pemphigus is a rare autoimmune skin disease that is always associated with a neoplasm. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by paraneoplastic pemphigus patients. The pathogenesis of paraneoplastic pemphigus is not yet completely understood, although some immunological aspects have been recently clarified. Because of its rarity, several di...