Investigation of the benzopyranones from the roots of PELARGONIUM SIDOIDES led to the identification of 15 benzopyranones, among them the novel compounds 12 and 14. Furthermore, benzopyranones 4 and 15 were detected in PELARGONIUM SIDOIDES for the first time. Structure determinations were performed by one- and two-dimensional NMR spectroscopy. An HPLC system for the discrimination of these benz...

Z. Naturforsch. 55c, 5 2 8 -5 3 3 (2000); received April 5/April 20. 2000 Pelargonium Species, Umckaloabo, Coumarins, Oxygenation Pattern The coumarin patterns of Pelargonium sidoides DC. and Pelargonium reniforme CURT., forming the origin of the herbal medicine “umckaloabo”, were analysed and compared for therapeutic equivalence. For both species, members of triand tetraoxygenated coumarins al...

The immunostimulating effect of Pelargonium reinforme / sidoides extract (Kalobin) against Prohemistomum vivax infection in mice was investigated. Five groups of mice were constructed. The first group was not treated nor infected and considered as control, the second group; control infected, was not treated but orally infected with 150 P. vivax metacercareae. The third, fourth and fifth groups ...

Aim: In this study we aimed to search the antibacterial effect of the drugs with active ingredients of Pelargonium sidoides on different bacterial species isolated from the throat cultures of patients with upper airway infection. Methods: Antibacterial activity on 72 Streptococci, 48 Stapyhlococcus, 32 Neisseriae spp, 20 Moraxella catarrhalis, and 20 Haemophilus influenzae was evaluated by usin...

conclusions eps 7630 was found to be efficacious in the treatment of acute tonsillopharyngitis in children and was very well tolerated. methods in this double-blind placebo-controlled clinical trial with a group sequential design, the efficacy and tolerability of eps 7630 were investigated in 6- to 10-year-old patients with acute tonsillopharyngitis, who showed no evidence of group a β-hemolyti...

OBJECTIVE This parallel controlled clinical trial evaluated the effect of a gel containing Lippia sidoides essential oil on plaque and gingivitis control. METHODS Thirty patients (n=30) were randomly selected and allocated into three groups: Lippia sidoides (LS, n=10), chlorhexidine (CLX, n=10) or placebo (control, n=10). Plaque and bleeding index were recorded at baseline and after three mon...

Background In numerous randomized controlled trials (RCTs) and systematic reviews such as those published by the Cochrane Collaboration, Pelargonium sidoides extract EPs® 7630 was shown to be effective in acute respiratory tract infections (aRTI) in all investigated age-groups. This narrative review focuses on recently published results from RCTs investigating the clinical efficacy and safety o...

Herb-induced liver injury (HILI) has recently attracted attention due to increasing reports of hepatotoxicity associated with use of phytotherapeutics. Here, we present data on HILI from the Berlin Case-Control Surveillance Study. The study was initiated in 2000 to investigate the serious toxicity of drugs including herbal medicines. Potential cases of liver injury were ascertained in more than...