Objective(s): It has been demonstrated that hydrogen sulfide plays a vital role in physiological and pathological processes such as regulating inflammation, oxidative stress, and vessel relaxation. The aim of the study was to explore the effect of hydrogen sulfide on angiogenesis in the ischemic adductor muscles of type 2 diabetic db/db mice and ischemic diabetic wound...

Background and Objectives: Curcumin and exercise training are suggested to improve hepatic disorders. The aim of this study was to investigate effects of two weeks of swimming training and curcumin supplementation on platelet-derived growth factor (PDGF-BB) and transforming growth factor beta 1 (TGF-β1) gene expressions following ethanol consumption in Wistar male rats. Materials and Methods: ...

Abstract Background Platelet-derived growth factor (PDGF) signalling is essential in the development and maintenance of neurovasculature. Of particular importance PDGFRβ for recruitment mural cell type pericytes, which occupy an important position coordinating blood-brain barrier functions. The PDGF pathway also implicated glioblastoma, where overexpression PDGFRα a signature proneural subtype ...

background: effects of platelet-derived growth factor b (pdgf-b) on peripheral nerve regeneration was studied using a rat sciatic nerve transection model. materials and methods: forty‑five male, white wistar rats were divided into three experimental groups (n = 15), randomly: normal control group (nc), silicon group (sil), and pdgf‑b treated group (sil/pdgf). in nc group, left sciatic nerve was...

Abstract Early detection and adjuvant therapies have significantly improved survival of patients with breast cancer over the past three decades. In contrast, management metastatic disease remains unresolved. Brain metastasis is a late complication frequently observed among cancer, whose poor prognosis calls for novel more effective therapies. Here, we report that active hypoxia inducible factor...

Background & Aims of the Study: Oxidative stress increases platelet-derived growth factor (PDGF) gene expression in endothelial cells that contributes to vascular dysfunction and atherosclerosis. Oxidative stress generates by dys-regulated redox balance between ROS producing systems and antioxidant systems. Also, Curcumin (Cur) as a main part of tur...