نتایج جستجو برای: pde3b

تعداد نتایج: 110  

Journal: :The Biochemical journal 1999
S Resjö A Oknianska S Zolnierowicz V Manganiello E Degerman

Phosphodiesterase type 3B (PDE3B) has been shown to be activated and phosphorylated in response to insulin and hormones that increase cAMP. In order to study serine/threonine protein phosphatases involved in the regulation of rat adipocyte PDE3B, we investigated the phosphorylation and activation of PDE3B in vivo in response to phosphatase inhibitors and the dephosphorylation and deactivation o...

Journal: :Cellular signalling 2006
Rebecka Nilsson Faiyaz Ahmad Karl Swärd Ulrika Andersson Marie Weston Vincent Manganiello Eva Degerman

Caveolae, plasma membrane invaginations particularly abundant in adipocytes, have been suggested to be important in organizing insulin signalling. Insulin-induced activation of the membrane bound cAMP degrading enzyme, phosphodiesterase 3B (PDE3B) is a key step in insulin-mediated inhibition of lipolysis and is also involved in the regulation of insulin-mediated glucose uptake and lipogenesis i...

Journal: :Molecular and cellular biology 1999
T Kitamura Y Kitamura S Kuroda Y Hino M Ando K Kotani H Konishi H Matsuzaki U Kikkawa W Ogawa M Kasuga

Cyclic nucleotide phosphodiesterase (PDE) is an important regulator of the cellular concentrations of the second messengers cyclic AMP (cAMP) and cGMP. Insulin activates the 3B isoform of PDE in adipocytes in a phosphoinositide 3-kinase-dependent manner; however, downstream effectors that mediate signaling to PDE3B remain unknown. Insulin-induced phosphorylation and activation of endogenous or ...

2013
Emilia Heimann Amitabh Sharma Nalini Raghavachari Vincent C. Manganiello Lena Stenson Eva Degerman

Islets from RIP-PDE3B mice, exhibiting β-cell specific overexpression of the cAMP/cGMP-degrading enzyme phosphodiesterase 3B (PDE3B) and dysregulated insulin secretion, were subjected to microarray analysis. We show that osteopontin (OPN) mRNA is increased in a dose-dependent manner in islets from RIP-PDE3B mice, as compared to wild-type islets. In addition, in silico analysis shows that PDE3B ...

Journal: :The Biochemical journal 2007
Faiyaz Ahmad Rebecka Lindh Yan Tang Marie Weston Eva Degerman Vincent C Manganiello

Fractionation of 3T3-L1 adipocyte membranes revealed that PDE3B (phosphodiesterase 3B) was associated with PM (plasma membrane) and ER (endoplasmic reticulum)/Golgi fractions, that insulin-induced phosphorylation/activation of PDE3B was greater in internal membranes than PM fractions, and that there was no significant translocation of PDE3B between membrane fractions. Insulin also induced forma...

Journal: :PLoS ONE 2009
Karin Berger Rebecka Lindh Nils Wierup Emilia Zmuda-Trzebiatowska Andreas Lindqvist Vincent C. Manganiello Eva Degerman

Cyclic nucleotide phosphodiesterases (PDEs) are important regulators of signal transduction processes mediated by cAMP and cGMP. One PDE family member, PDE3B, plays an important role in the regulation of a variety of metabolic processes such as lipolysis and insulin secretion. In this study, the cellular localization and the role of PDE3B in the regulation of triglyceride, cholesterol and gluco...

2016
Faiyaz Ahmad Youn Wook Chung Yan Tang Steven C. Hockman Shiwei Liu Yusuf Khan Kevin Huo Eric Billings Marcelo J. Amar Alan T. Remaley Vincent C. Manganiello

Activation of inflammation in white adipose tissue (WAT), includes infiltration/expansion of WAT macrophages, contributes pathogenesis of obesity, insulin resistance, and metabolic syndrome. The inflammasome comprises an intracellular sensor (NLR), caspase-1 and the adaptor ASC. Inflammasome activation leads to maturation of caspase-1 and processing of IL1β, contributing to many metabolic disor...

2002
Hiroshi Onuma Haruhiko Osawa Kazuya Yamada Takahiro Ogura Fumiko Tanabe Daryl K. Granner Hideichi Makino

Phosphodiesterase (PDE)-3B, a major PDE isoform in adipocytes, plays a pivotal role in the antilipolytic action of insulin. Insulin-induced phosphorylation and activation of PDE3B is phosphatidylinositol 3-kinase (PI3-K) and Akt dependent, but the precise mechanism of PDE3B activation is not fully understood. We have identified 14-3-3 , a critical scaffolding molecule in signal transduction, as...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Youn Wook Chung Claudia Lagranha Yong Chen Junhui Sun Guang Tong Steven C Hockman Faiyaz Ahmad Shervin G Esfahani Dahae H Bae Nazari Polidovitch Jian Wu Dong Keun Rhee Beom Seob Lee Marjan Gucek Mathew P Daniels Christine A Brantner Peter H Backx Elizabeth Murphy Vincent C Manganiello

Although inhibition of cyclic nucleotide phosphodiesterase type 3 (PDE3) has been reported to protect rodent heart against ischemia/reperfusion (I/R) injury, neither the specific PDE3 isoform involved nor the underlying mechanisms have been identified. Targeted disruption of PDE3 subfamily B (PDE3B), but not of PDE3 subfamily A (PDE3A), protected mouse heart from I/R injury in vivo and in vitro...

2016
Yongmin Yan Wenqian Jiang Jingwen Liu Wenrong Xu Hui Qian

BACKGROUND Phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) play a critical role in the regulation of intracellular level of adenosine 3´,5´-cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3´,5´-cyclic monophosphate (cyclic GMP, cGMP). Subsequently PDE3 inhibitors have shown to relax vascular and inhibit platelet aggregation in cardiovascular disease. OBJECTIVES In this stu...

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