نتایج جستجو برای: pde3a

تعداد نتایج: 120  

Journal: :The EMBO journal 2006
Seung Jin Han Sergio Vaccari Taku Nedachi Carsten B Andersen Kristina S Kovacina Richard A Roth Marco Conti

cGMP-inhibited cAMP phosphodiesterase 3A (PDE3A) is expressed in mouse oocytes, and its function is indispensable for meiotic maturation as demonstrated by genetic ablation. Moreover, PDE3 activity is required for insulin/insulin-like growth factor-1 stimulation of Xenopus oocyte meiotic resumption. Here, we investigated the cAMP-dependent protein kinase B (PKB)/Akt regulation of PDE3A and its ...

Journal: :The Journal of biological chemistry 2002
Jeremy Wechsler Young-Hun Choi Judith Krall Faiyaz Ahmad Vincent C Manganiello Matthew A Movsesian

PDE3A cyclic nucleotide phosphodiesterases regulate cAMP- and cGMP-mediated intracellular signaling in cardiac myocytes. We used antibodies to different regions of PDE3A to demonstrate the presence of three PDE3A isoforms in these cells. These isoforms, whose apparent molecular weights are 136,000, 118,000, and 94,000 ("PDE3A-136," "PDE3A-118," and "PDE3A-94"), are identical save for the deleti...

Journal: :The Biochemical journal 2005
Mercedes Pozuelo Rubio David G Campbell Nicholas A Morrice Carol Mackintosh

PDE3A (phosphodiesterase 3A) was identified as a phosphoprotein that co-immunoprecipitates with endogenous 14-3-3 proteins from HeLa cell extracts, and binds directly to 14-3-3 proteins in a phosphorylation-dependent manner. Among cellular stimuli tested, PMA promoted maximal binding of PDE3A to 14-3-3 proteins. While p42/p44 MAPK (mitogen-activated protein kinase), SAPK2 (stress-activated prot...

2010
Himabindu Penmatsa Weiqiang Zhang Sunitha Yarlagadda Chunying Li Veronica G. Conoley Junming Yue Suleiman W. Bahouth Randal K. Buddington Guangping Zhang Deborah J. Nelson Monal D. Sonecha Vincent Manganiello Jeffrey J. Wine Anjaparavanda P. Naren

Formation of multiple-protein macromolecular complexes at specialized subcellular microdomains increases the specificity and efficiency of signaling in cells. In this study, we demonstrate that phosphodiesterase type 3A (PDE3A) physically and functionally interacts with cystic fibrosis transmembrane conductance regulator (CFTR) channel. PDE3A inhibition generates compartmentalized cyclic adenos...

2017
Dong Keun Rhee Steven C. Hockman Sunkyung Choi Yong-Eun Kim Chungoo Park Vincent C. Manganiello Kee K. Kim

Phosphodiesterase 3A (PDE3A), a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (PDE) family, plays important roles in oocyte maturation and vascular smooth muscle cell proliferation. However, the molecular mechanisms that regulate PDE3A gene expression remain largely unknown. In this study, we investigated the transcriptional regulation of PDE3A , and found that the splicing f...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Bo Ding Jun-Ichi Abe Heng Wei Haodong Xu Wenyi Che Toru Aizawa Weimin Liu Carlos A Molina Junichi Sadoshima Burns C Blaxall Bradford C Berk Chen Yan

cAMP plays crucial roles in cardiac remodeling and the progression of heart failure. Recently, we found that expression of cAMP hydrolyzing phosphodiesterase 3A (PDE3A) was significantly reduced in human failing hearts, accompanied by up-regulation of inducible cAMP early repressor (ICER) expression. Angiotensin II (Ang II) and the beta-adrenergic receptor agonist isoproterenol (ISO) also induc...

Journal: :Circulation research 2013
Sanja Beca Faiyaz Ahmad Weixing Shen Jie Liu Samy Makary Nazari Polidovitch Junhui Sun Steven Hockman Youn Wook Chung Matthew Movsesian Elizabeth Murphy Vincent Manganiello Peter H Backx

RATIONALE cAMP is an important regulator of myocardial function, and regulation of cAMP hydrolysis by cyclic nucleotide phosphodiesterases (PDEs) is a critical determinant of the amplitude, duration, and compartmentation of cAMP-mediated signaling. The role of different PDE isozymes, particularly PDE3A vs PDE3B, in the regulation of heart function remains unclear. OBJECTIVE To determine the r...

2017
Pierre Vandenberghe Perrine Hagué Steven C. Hockman Vincent C. Manganiello Pieter Demetter Christophe Erneux Jean-Marie Vanderwinden

We previously identified phosphodiesterase 3A (PDE3A) as a marker for interstitial cells of Cajal (ICC) in adult mouse gut. However, PDE3A expression and function during gut development and in ICC-derived gastrointestinal stromal tumors (GIST) remained unknown. Here we found that PDE3A was expressed throughout ICC development and that ICC density was halved in PDE3A-deficient mice. In the human...

Journal: :European review for medical and pharmacological sciences 2017
F-M Tian C-Y Zhong X-N Wang Y Meng

OBJECTIVE In this study, we aimed to investigate the mechanism of PDE3A downregulation in chemoresistant non-small cell lung cancer (NSCLC) cells, its functional role in chemotherapy response and association with survival outcomes. MATERIALS AND METHODS The raw data of GDS5247 was downloaded from GEO datasets and reanalyzed. The expression of PDE3A in patients with NSCLC and its DNA methylati...

2007
Wei Zhang Robert W Colman Sol Sherry Robert W. Colman

Thrombin-induced cAMP reduction potentates several steps in platelet activation, including Ca mobilization, cytoskeletal reorganization, and fibrinogen receptor conformation. We now reinvestigate the signaling pathways by which intracellular cAMP content is controlled following platelet activation by thrombin. When washed human platelets were stimulated with thrombin, cAMP-dependent phosphodies...

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