Formation of mixed-ligand Pd2+ complexes between canonical nucleoside 5'-monophosphates and five metal-ion-binding nucleoside analogs has been studied by 1H-NMR spectroscopy to test the ability of these nucleoside surrogates to discriminate between unmodified nucleobases by Pd2+-mediated base pairing. The nucleoside analogs studied included 2,6-bis(3,5-dimethylpyrazol-1-yl)-, 2,6-bis(1-methylhy...

The catalytic activity of natural and synthetic zeolites modified by ion exchange with cations Ni2+, Zn2+, Cu2+, Co2+, Bi2+ Pd2+ in the reaction propylene oxidative conversion molecular oxygen to acrolein was studied. Based on experimental data, it found that clinoptilolite Ni2+ cation exhibits highest selectivity question. conditions were studied

We have previously demonstrated that the neonatal corticosterone response to acute hypoxia shifts from ACTH independence to ACTH dependence between postnatal days two (PD2) and eight (PD8). Cyclic AMP (cAMP) is the obligatory intracellular second messenger of ACTH action, and we hypothesized that corticosterone production in neonatal rats shifts from a cAMP-independent mechanism to cAMP-depende...

Influence of the axial ligand of PD1 chlorophyll (D1-His-198) on the Em of monomer chlorophylls PD1 and PD2, and the PD1•+/PD2•+ charge ratio was investigated by theoretical calculations using the PSII crystal structure of Thermosynechococcus vulcanus analyzed at 1.9-Å resolution. It was found that the Em(PD1)/Em(PD2) values and PD1•+/PD2•+ ratio remained unchanged upon D1-H198Q mutation. Howev...

This research describes the preparation and sensor applications of multifunctional monodisperse, Fe₃O₄ nanoparticles-embedded poly(styrene)/poly(thiophene) (Fe₃O₄-PSt/PTh), core/shell nanoparticles. Monodisperse Fe₃O₄-PSt/PTh nanoparticles were prepared by free-radical combination (mini-emulsion/emulsion) polymerization for Fe₃O₄-PSt core and oxidative seeded emulsion polymerization for PTh she...

Pancreatic differentiation 2 (PD2), an important subunit of the human PAF complex, was identified after differential screening analysis of 19q13 amplicon, and its overexpression induces oncogenic transformation of NIH3T3 cells, hence raising the possibility of a role for PD2 in tumorigenesis and metastasis. To test this hypothesis, we analyzed here the functional role and clinical significance ...

The complexation reactions between Cu2+, Pd2+ and Ni2+ metal ions with promethazine (PM) in water or DMF were studied by the spectrophotometric methods at [(15, 25,35 and 45±0.1) °C]. The complexation process was optimized in terms of pH, temperature and contact time. The stoichiometry of the complex was found to be 1:1 (metal ion/ligand). The formation constants of the resulting complexes were...

Cancer stem cells (CSCs), which mediate drug resistance and disease recurrence in several cancers, are therapeutically relevant to ovarian cancer (OC), wherein approximately 80% of patients manifest with tumor recurrence. While there are several markers for ovarian CSCs (OCSCs), the mechanism for their self-renewal maintenance by unique driver/markers is poorly understood. Here, we evaluated th...

In the crystal structure of the title compound, [Pd2(C36H42N6)Cl2](ClO4)2·2C3H7NO·2CH3OH, the dinuclear Pd(II) complex cation lies on an inversion center. Each Pd(II) ion has a distorted square-planar coordination sphere, defined by three N atoms of the macrocyclic ligand and a chloride ion. The Pd(II) complex cations and the methanol mol-ecules are linked through N-H⋯O and O-H⋯O hydrogen bonds...