objective: crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. the present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. materials and methods: local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hin...

This investigation was performed in order to assess the inflammatory response induced by Naja haje arabica venom (NhaV) in rat hind paw. The inflammatory response was estimated by measuring the edema with a Plethysmometer. The venom (0.625-10μg/paw) produced a dose and timedependent increase in non-hemorrhagic paw edema. The response to NhaV was maximal within 15 min and disappeared in 24 h. Fi...

Anti-inflammatory potency of 5-hydroxypyrimidine derivatives SNK-411 (2-isobutyl-4,6-dimethyl-5-hydroxypirimidine) and SNK-578 (hydrochloride 2-isobutyl-4,6-dimethyl-5-hydroxypirimidine) was evaluated on the model complete Freund`s adjuvant (CFA)-induced exudative inflammation in experiment 60 outbreed male rats weighing 180–200 g comparison with prednisolone. Prednisolone, were injected twice:...

background: inflammation is a dynamic process that is elicited in response to various harmful stimulantsthat may threaten the well-being of the host. herbs have been traditionally used as anti-inflammatory agents since very early times. rubia tinctorum l. is one of these herbs that havebeen used for treating inflammatory diseases in iranian traditional medicine. objective: this study aims at co...

Evaluation of the effect of hydroalcoholic extracts of Cassia occidentalis in paw edema induced by Carrageenan in Rats. The effect of oral administration of hydroalcoholic extract of Cassia occidentalis seeds on carrageenan induced inflammation has been studied and is compared with the effect of oral administration of Diclofenac sodium as standard on rats. A carrageenan resulted in paw edema. S...

Carrageenan produces both inflammation and pain when injected in mouse paws via enhancement of reactive oxygen species formation. We have investigated an effect of astaxanthin extracted from Litopenaeus vannamei in carrageenan-induced mice paw edema and pain. The current study demonstrates interesting effects from astaxanthin treatment in mice: an inhibition of paw edema induced in hind paw, an...

the effects of hydroalcoholic extract (he) of curculigo orchioides gaertn. rhizome (hypoxidaceae) and its alkaloidal and non-alkaloidal fractions (af) and (naf) were evaluated in carrageenan-induced paw edema experimental models of inflammation. the oral administration of he, their af and naf fractions were used at doses of 100, 300 and 500 mg/kg. the effect produced by the he, af and naf fract...

objective(s): fluvoxamine is a well-known selective serotonin reuptake inhibitor (ssri); despite its anti-inflammatory effect, little is known about the precise mechanisms involved. in our previous work, we found that ip administration of fluvoxamine produced a noticeable anti-inflammatory effect in carrageenan-induced paw edema in rats. in this study, we aimed to evaluate the effect of fluvoxa...