in medicine, patent blue violet (pbv) is utilized for staining lymphatic vessels in sentinel lymph node (sln) surgery. moreover, pbv (also called e131 ) is used as food additive. we report on a 51-year-old non-atopic female with early breast cancer, who was scheduled for sln excision and experienced an intra-operative anaphylactic reaction. in diagnostics the skin prick test (spt) was positive ...

The title compound, C(8)H(10)N(2)O(2)S, was prepared by the reaction of 2-cyano-3,3-bis-(methyl-sulfan-yl)acrylate and 2-amino-ethanethiol at 350 K. The mol-ecular structure and packing are stabilized by N-H⋯O hydrogen-bond inter-actions. All the non-H atoms are nearly in the same plane with the maximum deviation being 0.08 Å.

In the title compound, C(26)H(28)O(2)S, the dihedral angles between the mean plane of the five membered ring and the 4-(methyl-sulfan-yl)benzyl-idine ring in the two crystallographically independent mol-ecules are 34.05 (10) and 40.53 (15)°. The packing is stabilized by inter-molecular O-H⋯O and C-H⋯O inter-actions.

(51) Int. Cl. A61B 5100 A61B 8100 A61B 10100 (2006.01) (2006.01) (2006.01) (52) U.S. Cl. USPC ............ 424/9.6; 424/1.11; 424/1.65; 424/9.1 ( 58) Field of Classification Search USPC ............ 424/1.11, 1.65, 9.1, 9.2, 9.3, 9.4, 9.5, 424/9.6; 534/550; 540/450; 546/1, 152, 546/184, 249; 548/100, 146, 215, 300.1, 548/400, 950; 549/1, 200; 568/300, 700 See application file for complete searc...

Highly emitting 8-propargylaminoBODIPY (8-PAB) 2 was prepared in 94% yield. Unlike any other BODIPY structure hitherto described in the literature, 2 displays efficient emission in the blue region of the visible spectrum with a fluorescence quantum yield up to 0.94 and high laser efficiency (35%) at 483 nm.

Our novel quality index is based on citations from international search reports and provides internationally comparable, quality-adjusted figures for applications made under the Patent Cooperation Treaty (PCT). We show that China’s recent patent expansion has taken place to the detriment of patent quality. Weighting national PCT counts with our index reveals a widening gap between the technolog...

In eBay, Inc. v. MercExchange, LLC, ___ S.Ct. ___ (May 15, 2006), a unanimous United States Supreme Court abrogated the Federal Circuit’s “general rule” that a permanent injunction will issue once a patent is adjudged valid and infringed. In a concurring opinion for four of the eight Justices that considered eBay, Justice Kennedy singled out cases involving patent trolls and business method pat...