conclusions the results of the study show that tadalafil can increase the mean ielt and can be used for treatment of premature ejaculation in combination with paroxetine. results the mean age of patients in groups a and b were 33 ± 9.6 and 31.2 ± 9.3 years, respectively (p = 0.368). the mean number of intercourses were 1.08 ± 0.6 and 1.12 ± 0.6 per week in groups a and b, respectively (p = 0.79...

BACKGROUND Several recent studies have investigated the therapeutic role of phosphodiesterase type 5 (PDE5) inhibitors in premature ejaculation (PE) used in the treatment of erectile dysfunction. OBJECTIVES In the present research, the efficacy of paroxetine alone and paroxetine plus tadalafil was compared in patients referred because of premature ejaculation. PATIENTS AND METHODS This quas...

Introduction: Although the effectiveness of paroxetine and Attention Modification Program has been studied separately in treating social anxiety disorder, there has been no research comparing them according to the literature. The aim of this study was to compare the effectiveness of paroxetine, Attention Modification Program (AMP) and combination of both on improving the Social Anxiety Symptoms...

Background: P2X4 receptor (P2X4R), a purinoceptor expressed in activated spinal microglia, plays a key role in the pathogenesis of neuropathic pain. Spinal nerve injury induces up-regulation of P2X4R on activated microglia in the spinal cord, and blockade of this receptor can reduce neuropathic pain. The present study was undertaken to determine whether paroxetine, an inhibitor of P2X4R, could ...

background: some antidepressant drugs can promote neuronal cell proliferation in vitro as well as hippocampal neurogenesis in human and animal models. furthermore, adipose tissue is an available source of adult stem cells with the ability to differentiate in to multiple lineages. therefore, human adipose-derived stem cells (hadscs) may be a suitable source for regenerative medical applications....

background: p2x4 receptor (p2x4r), a purinoceptor expressed in activated spinal microglia, plays a key role in the pathogenesis of neuropathic pain. spinal nerve injury induces up-regulation of p2x4r on activated microglia in the spinal cord, and blockade of this receptor can reduce neuropathic pain. the present study was undertaken to determine whether paroxetine, an inhibitor of p2x4r, could ...

Aims:Memory deficit is the most visible symptom of cerebral ischemia. The hippocampus is sensitive against cerebral ischemia. Oxidative stress and inflammation are involved in the pathological process after cerebral ischemic injury. Paroxetine has anti-oxidative and anti-inflammatory effects. In this study the effect of paroxetine on memory deficit after cerebral ischemia was investigated. Meth...

Aims:Memory deficit is the most visible symptom of cerebral ischemia. The hippocampus is sensitive against cerebral ischemia. Oxidative stress and inflammation are involved in the pathological process after cerebral ischemic injury. Paroxetine has anti-oxidative and anti-inflammatory effects. In this study the effect of paroxetine on memory deficit after cerebral ischemia was investigated. Meth...

introduction: although the effectiveness of paroxetine and attention modification program has been studied separately in treating social anxiety disorder, there has been no research comparing them according to the literature. the aim of this study was to compare the effectiveness of paroxetine, attention modification program (amp) and combination of both on improving the social anxiety symptoms...

Background: Neuropathic pain due to damage to the peripheral nerve has influenced millions of people living all over the world. It has been shown that paroxetine can relieve neuropathic pain. Recently, the role of some proteins like BDNF, GABAA receptor, and KCC2 transporter in the occurrence of neuropathic pain has been documented. In the current study, the expression of these proteins affecte...