The biosynthesis, processing, and secretion of parthormone and the effect of calcium on these processes were measured in dispersed porcine parthyroid cells incubated with [(35)S]methionine. Proparathormone was detected at 10 min, the earliest time measured, and was rapidly and apparently quantitatively converted to parathormone. The half-life of the prohomormone pool was 15 min. Secretion of pa...

Secondary hyperparathyroidism is a complication of chronic kidney disease, and it develops due to abnormal regulation of calcium and phosphate homeostasis (1). Various factors interact in its development. They are consist of decrease kidney synthesis of 1,25-dihydroxyvitamin D, the, phosphorus retention and impaired calcemic response to parathyroid hormone (1,2). Hence, increasing of parathormo...

1. A very large single dose of parathormone produced rapid and extensive decalcification of the bones of a young rabbit. 2. Gradually increased doses of parathormone failed to produce significant changes in the bones of young and fully grown adult rabbits. 3. Ammonium chloride, administered by stomach tube was without effect on the bones, when given to rabbits treated with parathormone or to ot...

Parathyroid specimens removed from patients with clinical hyperparathyroidism were cultured in a two-layer soft-agar system. Four patients had parathyroid hyperplasia and one had a parathyroid adenoma. Colonies grew from single-cell suspensions of each specimen. Plating efficiency ranged from 0.001 to 0.05%. No colonies grew from normal bovine parathyroid specimens. Parathormone was detected in...

The effect of ACTH, adrenaline, noradrenaline, insulin, parathormone, hydrocortisone,and glucagonon the homeostaticmechanismcontrolling serum glucose,citrate, calcium, phosphorus,and potassium was studied in fasting rabbits and children. Citrate levelsare kept in balancebyACTH, adrenaline,and glucagon,which raisethe levels,and by insulin,which lowers them. Stressalone raisescitrate levels,proba...

OBJECTIVE To determine the correlation between left ventricular mass index and calcium metabolism in patients with essential hypertension. STUDY DESIGN Cross sectional case-control study. MATERIAL AND METHODS Twenty-seven patients with essential hypertension and 20 healthy individuals were compared with respect to calciotropic hormones, left ventricular mass index (LVMI), and urinary and se...

1. On a low calcium intake hypercalcemia tended to disappear in chronic hyperparathyroidism on a given dose of parathormone (as large as 6 units per kg.), apparently due to the reduction of a readily available calcium reserve. An increase of either the calcium intake or of the daily dose of parathormone caused a rise of serum calcium and symptoms of overdosage. 2. Hypocalcemia developed in chro...

The conversion of proparathyroid hormone (proparathormone) to parathyroid hormone (parathormone) by subcellular fractions of the bovine parathyroid has been investigated. The identification of the conversion product as parathormone was established by its elution postion during ion exchange chromatography and gel filtration, and by partial amino acid sequence analysis of its NH2-terminal region....

These studies have shown that the bones of guinea pigs given daily injections of parathormone from the age of 2 to 7 days to the age of 110 to 120 days, show relatively very little effect after receiving 20 units daily during the last 65 to 87 days of treatment. But it is probable that their bones underwent decalcification early in the treatment and that subsequently the parathormone, continued...

Objective: Primary hyperparathyroidism (PHPTH) is an endocrine disorder with hypercalcemia due to increased parathormone (PTH) release. This study aims investigate the relationship between PHPTH and serum zinc copper levels.