An online PubMed database search was conducted using the following algorithm: ('papaverine'[All Fields] OR 'papaverine'[MeSH Terms] 'papaverine'[All Fields]) AND ('intracisternal'[All Fields]. Only articles that attributed oculomotor nerve palsy solely to intracisternal Papaverine were further analysed.

The research was conducted with the aim of examining alkaloids content twelve poppies (Papaver somniferum L.) cultivars registered in Turkey by correlation and path analysis relationships among capsule yield. field experiments were set up according to a randomized complete block design three replications 2017-18 2018-19 under semi-arid ecological conditions Isparta, Turkey. differences yields a...

AIM To investigate the effect of locally administered intracisternal papaverine on the pupils during cerebral aneurysm clipping. MATERIAL AND METHODS Four patients that received cerebral aneurysm clipping were included in the study. Papaverine (3%, 60 mg) was dropped into the internal carotid artery cistern to relieve vascular spasm and act on the oculomotor nerve intentionally at the same ti...

Papaverine, 1-[(3,4-dimethoxyphenyl)methyl]-6,-7-dimethoxyisoquinoline, has been used as a vasodilator agent and a therapeutic agent for cerebral vasospasm, renal colic, and penile impotence. We examined the effects of papaverine on a rapidly activating delayed rectifier K(+) channel (hKv1.5) cloned from human heart and stably expressed in Ltk(-) cells as well as a corresponding K(+) current (t...

AIM Papaverine is a vasodilator agent that is an opium alkaloid. It exhibits its effects by inhibiting phosphodiesterase enzyme. Papaverine administration is widely used to avoid symptomatic vasospasm after subarachnoid hemorrhage. We aim in this research to study the effects of papaverine on the epileptic discharges stimulated by penicillin. MATERIAL AND METHODS Adult female Wistar rats (220...

The metabolism of papaverine, the opium benzylisoquinoline alkaloid, with Aspergillus niger NRRL 322, Beauveria bassiana 22864, Cunninghamella echinulate ATCC 18968 and 1382 has resulted in O-demethylation, O-methylglucosylation N-oxidation products. Two new metabolites (4″-O-methyl-β-D-glucopyranosyl) 4′-demethyl papaverine 6-demethyl (Metabolites 5 6) together 4′-O-demethylated (Metabolite 1)...

This article concerns the synthesis and biological activities of some N-(1-(3,4-dimethoxyphenyl)propan-2-yl) amides as isoquinoline precursors compounds with smooth muscle (SM) relaxant activity. Aim: find activity compare it papaverine, an alkaloid that has been known a brain coronary vasodilator SM relaxant. Materials methods: In silico simulation PASS online program predicts for compounds. T...

The replication of HVJ (Sendai virus) in C6 rat glial cells was found to be inhibited by treatment of the cells with papaverine, an inhibitor of cAMP phosphodiesterase, but not with cAMP or dibutyryl cAMP. In addition, cyclic GMP which often manifests a reciprocal relationship to cAMP did not counteract the inhibition of HVJ yield by papaverine. Both viral genome replication and transcription w...

1. Papaverine, in the concentration range 50-150 microM, inhibited rhythmic spontaneous contraction and caused relaxation of KCl-induced contractures of rat ileal smooth muscle. 2. Spontaneous slow waves and spikes declined at low papaverine concentrations. 3. The normal 45Ca uptake of the ileum was reduced by papaverin. Although papaverine caused only a small inhibition of normal 45Ca efflux f...

The benzylisoquinoline alkaloid papaverine, synthesized in low amount in most of the opium poppy varieties of Papaver somniferum, is used as a vasodilator muscle relaxant and antispasmodic. Papaverine biosynthesis remains controversial as two different routes utilizing either (S)-coclaurine or (S)-reticuline have been proposed with uncharacterized intermediate steps. In an attempt to elucidate ...