BACKGROUND KL-6, a human MUC1 mucin, is a sensitive biomarker for interstitial lung diseases including pulmonary alveolar proteinosis (PAP). A correlation between MUC1 gene single nucleotide polymorphism (SNP) rs4072037 genotype and serum KL-6 levels has been reported. This study was aimed at investigating the correlation between MUC1 SNP genotype, severity of disease and disease outcome in PAP...

In this work, we report the thermal kinetics, thermodynamics, and decomposition mechanism of AP-based molecular perovskite energetic materials estimate their safety performance. Typical materials, (H 2 dabco)[NH 4 (ClO ) 3 ] (DAP-4), pz)[NH ](PAP-4), mpz)[NH ](PAP-M4), hpz)[NH (PAP-H4), were synthesized characterized. These studied using differential scanning calorimetry (DSC). The results show...

phosphatidate phosphohydrolase (pap) from cytosolic fraction of rat liver was purified to homogeneity having specific activity of 5.14 u/mg protein. an activity staining procedure was developed to determine molecular weight of the enzyme on polyacrylamide gel electrophoresis using ferguson plot. molecular weight (m.w.) of the active pap was 298 kda. sds-page analysis showed a m.w. of 47 kda for...

An experiment was performed to investigate the effect of animal vs. vegetable protein sources in the diet of laying hens on the development of hen performance. A diet containing protein sources of only vegetable origin was compared with 4 diets, each containing 1 of 4 processed animal proteins (PAP). Two PAP (Daka-58 and Sonac-60) were classified as meat meals, and the remaining 2 (Daka-40 and ...

Thrombotic thrombocytopenic purpura (TTP) is characterized by widespread platelet thrombi in arterioles and capillaries. Unusually large or multimeric von Willebrand factor, as well as one or more platelet-agglutinating factors, have been implicated in the pathogenesis of TTP. But, the actual mechanisms of platelet agglutination have not been satisfactorily explained. Recent studies suggested t...

Objectives: Interferon alpha-2b possesses variable activity against human papillomavirus (HPV) associated cervical intraepithelial neoplasia (CIN). No topical therapy is currently available for treatment of early stage CIN. We evaluated a new patented drug delivery technology in order to achieve topical efficacy. Methods: Two separate studies were conducted in parallel. IFN002 (treatment group)...

INTRODUCTION The aim of this study was to evaluate the frequency of unexplained pulmonary hypertension (PHT) among patients on hemodialysis at 2 centers and to evaluate possible predisposing factors. MATERIALS AND METHODS In this cross-sectional study, PHT was screened by Doppler echocardiography on the day after dialysis in 62 patients with end-stage renal disease receiving maintenance hemod...