An estimation method based on RP-HPLC has been identified for determining the concentrations of pantoprazole sodium and mosapride citrate in combined pharmaceutical formulation. The experiment was performed on Hypersil BDS (4.6mm X 150nm), 5μm column in isocratic mode, with 1 mL/min flow of orthophosphoric acid adjusted, mobile phase consisting of a 40:60 mixture of mixed sodium phosphate buffe...

This study is to prepare the pantoprazole sodium enteric-coated tablet which is compacted by pellets. The enteric-coated pantoprazole sodium pellets were prepared by fluid bed coating technology. The pantoprazole sodium enteric-coated tablets were prepared by direct compression of the enteric-coated pellets and suitable excipients. In vitro dissolution method and scanning electron microscope me...

DESCRIPTION The active ingredient in PROTONIX (pantoprazole sodium) Delayed-Release Tablets and PROTONIX (pantoprazole sodium) For Delayed-Release Oral Suspension is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid secretion. Its empirical formula is C16H14F2N3NaO4S x 1.5...

two sensitive spectrophotometric methods are presented for the assay of pantoprazole sodium sesqui hydrate (pnt) in bulk drug and in formulations using n-bromosuccinimide (nbs) and two dyes, methyl orange and indigo carmine, as reagents. the methods involve the addition of a known excess of nbs to pnt  in acid medium, followed by determination of unreacted oxidant by reacting with a fixed amoun...

A pencil graphite electrode modified with poly (bromocresol green (BCG)) was prepared by electro-polymerization process for the determination of pantoprazole sodium. The surface morphology and structure of poly (BCG) film were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The determination of pantoprazole sodium in Britton-Robinson buffer (pH 7.0) wa...

A simple, sensitive and precise high performance liquid chromatographic method for the analysis of Pantoprazole sodium and lansoprazole has been developed, validated and used for the determination of compounds in commercial pharmaceutical products. The compounds were well separated an isocratically on a C18 column [Use Inertsil C18, 5μ , 150 mm x 4.6 mm] utilizing a mobile phase consisting of a...

BACKGROUND The pantoprazole product available in Canada for IV administration has recently been reformulated to include ethylenediaminetetra-acetic acid (EDTA). The purpose of this study was to determine if the chemical stability of pantoprazole for injection containing EDTA (PANTO IV), admixed in polyvinyl chloride (PVC) minibags at concentrations of 0.16 mg/mL and 0.80 mg/mL in 5% dextrose in...

OBJECTIVE Three sensitive, selective, and precise spectrophotometric methods based on manipulation of ratio spectra, have been developed and validated for the determination of diclofenac sodium and pantoprazole sodium. MATERIALS AND METHODS The first method is based on ratio spectra peak to peak measurement using the amplitudes at 251 and 318 nm; the second method involves the first derivativ...