In bacteria, β-alanine is formed via the action of l-aspartate α-decarboxylase (PanD) which is one of the small class of pyruvoyl-dependent enzymes. The pyruvoyl cofactor in these enzymes is formed via the intramolecular rearrangement of a serine residue in the peptide backbone leading to chain cleavage and formation of the covalently-bound cofactor from the serine residue. This reaction was pr...

The postulated posttranslational modification of the polyhydroxybutyrate (PHA) synthase from Ralstonia eutropha by 4-phosphopantetheine was investigated. Four beta-alanine auxotrophic Tn5-induced mutants of R. eutropha HF39 were isolated, and two insertions were mapped in an open reading frame with strong similarity to the panD gene from Escherichia coli, encoding L-aspartate-1-decarboxylase (E...

pand-e piran is of the mystical texts has remained from fifth hegira century whose author is unknown. this work contains a set of parables with various subjects. one of the most prominent subjects n this work is sophism and mystics . the source of this work’s parables which is on famous sophists of third hegira century and their life style and majesty has remained unknown and is not mentioned t...

Sleep disorder, especially insomnia, is one of the most common panic disorder (PanD) comorbidities, with PanD and insomnia being closely related. severity definitely associated sleep while caused by abnormal anxiety. Insomnia management in patients based on a multidisciplinary approach to achieve emotional balance includes both medicinal treatment wide range psychotherapy methods. Successful co...

Technology advances have immensely accelerated large-scale mapping of biological networks, which necessitates the development of accurate and powerful network-based algorithms to make functional inferences. A prevailing approach is to leverage functions of neighboring nodes to predict unknown molecular function. However, existing neighbor-based algorithms have ignored the scale-free property hi...

In the study reported here, magnesium/aluminum (Mg/Al)-layered double hydroxide (LDH) was intercalated with an anticancer drug, protocatechuic acid, using ion-exchange and direct coprecipitation methods, with the resultant products labeled according to the method used to produce them: "PANE" (ie, protocatechuic acid-Mg/Al nanocomposite synthesized using the ion-exchange method) and "PAND" (ie, ...