Aim: To assess the effect of Omeprazole at neuromuscular junction with and without Pancuronium. Study design: Experimental randomized control study. Place duration study: Department Pharmacology, Islamic International Medical College, Rawalpindi from October 2018 to September 2019 Methods: In this experimental study both a student’s oscillograph cumulative dosage response curve were used record...

The interaction of pancuronium with sodium channels was investigated in squid axons. Sodium current turns on normally but turns off more quickly than the control with pancuronium 0.1-1mM present internally; The sodium tail current associated with repolarization exhibits an initial hook and then decays more slowly than the control. Pancuronium induces inactivation after the sodium inactivation h...

BACKGROUND AND OBJECTIVES The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental studies and in humans. The aim of this study was to evaluate in vitro the interaction between ropivacaine and pancuronium, the influence on tran...

stan-2b ,16b-ylene)bis(1-methyl-piperidinium) dibromide [15500-66-0] is general anaesthesia used in surgery for muscle relaxation and as an aid to endotracheal intubation (Chart 1). Several methods of determination of this drug have been reported in the literature, including high performance liquid chromatography (HPLC), capillary gas chromatography using nitrogen sensitive detection, liquid ch...

The effect of various non-depolarizing neuromuscular blocking agents (gallamine, pancuronium, vecuronium, d-tubocurarine, metocurine, atracurium and pipecuronium) on [3H]acetylcholine release in the response to field electrical stimulation was investigated in vitro in preparations of the guinea pig right atrium. In this preparation, atropine enhanced and oxotremorine, a muscarinic agonist, redu...

The antagonism, by neostigmine, of neuromuscular blockade produced by either Org NC 45 or pancuronium was studied in 29 anaesthetized patients during a continuous infusion of the myoneural blocker. The ED50 of neostigmine (dose which produced a 50% antagonism) when antagonizing Org NC 45 and pancuronium was 0.011 mg kg-1 and 0.010 mg kg-1 respectively. The dose-response relationships for the an...

The neuromuscular and cardiovascular activities of pancuronium were compared with those of its 16(3 monoquaternary congener, Org NC 45, in the anaesthetized rat, cat and rhesus monkey. In the rat Org NC 45 was 3.4 times less potent as a neuromuscular blocking agent than was pancuronium. In the cat, both drugs were found to be approximately equally eliminated by the liver, whereas renal eliminat...

PURPOSE To evaluate the effects of levobupivacaine on neuromuscular transmission and neuromuscular blockade produced by pancuronium in vitro. METHODS Thirty rats were distributed into groups (n = 5) according to the drug used alone or in combination: Group I - levobupivacaine (5 µg.mL-1); Group II - pancuronium (2 µg.mL-1); Group III - pancuronium (2 µg.mL-1) + levobupivacaine (5µg.mL-1). The...

anaphylactic reactions can occur following the adminstration of muscle relaxants. however, it happens very rarefy wish pancuronium bromide. a case report of anaphylactic shock to pancuronium bromide, which is supported by a highly poitive skin prick test, is reported.

The study was carried out to compare the intubating conditions, cardiovascular responses, neuro-muscular blocking properties and reversal characteristics of pipecuronium bromide and pancuronium bromide. This is a prospective hospital based study. 100 patients belonging to ASA grade I or II physical status aged 18 to 70 years were divided into two groups of 50 patients each. Group 1 received pip...