نتایج جستجو برای: pamam megamer

تعداد نتایج: 902  

Supramolecule self assembly polyamidoamine (PAMAM) dendrimer refers to the chemical systems made up of a discrete number of assembled molecular subunits or components. These strategies involve the covalent assembly of hierarchical components reactive monomers, branch cells or dendrons around atomic or molecular cores according to divergent/convergent dendritic branching principles, systematic f...

Journal: :iranian chemical communication 2014
omid louie abdoulhossien massoudi samaneh maghsoodi

supramolecule self assembly polyamidoamine (pamam) dendrimer refers to the chemical systems made up of a discrete number of assembled molecular subunits or components. these strategies involve the covalent assembly of hierarchical components reactive monomers, branch cells or dendrons around atomic or molecular cores according to divergent/convergent dendritic branching principles, systematic f...

Journal: :Soft matter 2013
Mallory A van Dongen S Vaidyanathan Mark M Banaszak Holl

The desire to synthesize soft supramolecular structures with size scales similar to biological systems has led to work in assembly of polymeric nanomaterials. Recent advances in the isolation of generationally homogenous poly(amidoamine) (PAMAM) dendrimer enables their use as quantized building blocks. Here, we report their assembly into precise nanoclusters. In this work, click-functional liga...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه پیام نور - دانشگاه پیام نور مرکز - دانشکده شیمی 1391

dendrimer synthesis strategies now provide virtual control of macromolecular nanostructures as a function of size and surface/interior functionality. these strategies involve the covalent assembly of hierarchical components reactive monomers , branch cells or dendron’s around atomic or molecular cores according to divergent/convergent dendrite branching principles.combinon of two or more dendri...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2007
Jianjun Chen Lu Chen Gang Wang Hong Tang

OBJECTIVE It remains elusive how CD40 endocytosis or clustering on the cell surface is induced by different forms of CD40 agonist. This study aims to investigate whether lipid rafts differentially regulate CD40 traffic and signaling in proinflammatory activation of cardiovascular endothelial cells (ECs). METHODS AND RESULTS Using fluorescent microscopy and flow cytometry, we demonstrated that...

2015
Yubin Li Haiyan Zhu Shaofei Wang Xiaolu Qian Jiajun Fan Ziyu Wang Ping Song Xuesai Zhang Weiyue Lu Dianwen Ju

Poly-amidoamine (PAMAM) dendrimers are proposed to be one of the most promising drug-delivery nanomaterials. However, the toxicity of PAMAM dendrimers on the central nervous system seriously hinders their medical applications. The relationship between oxidative stress and autophagy induced by PAMAM dendrimers, and its underlying mechanism remain confusing. In this study, we reported that PAMAM ...

2014
Ningning Wang Bin Liu Lili Liang Yanxin Wu Hongzhe Xie Jiaming Huang Xu Guo Jinfeng Tan Xuejun Zhan Yongdong Liu Liantang Wang Peiqi Ke

OBJECTIVE To evaluate the characteristics and antiangiogenic effects of endostatin-loaded PAMAM on endometriosis in a noninvasive animal model. MATERIALS AND METHODS A noninvasive animal model was established by injecting adenovirus-GFP transfected endometrial stromal and glandular epithelial cells subcutaneously into nude mice. Endostatin-loaded PAMAM was prepared and identified by transmiss...

2017
Xuefeng Qiu Kai Cao Tingsheng Lin Wei Chen Ahu Yuan Jinhui Wu Yiqiao Hu Hongqian Guo

Intravesical instillation of antitumor agents following transurethral resection of bladder tumors is the standard strategy for the treatment of superficial bladder cancers. However, the efficacy of current intravesical instillation is limited partly due to the poor permeability of the urothelium. We therefore aimed to develop a high-penetrating, target-releasing drug delivery system to improve ...

2012
Jean-Sebastian Mandeville Phillipe Bourassa Thekkumkattil John Thomas Heidar-Ali Tajmir-Riahi

Biogenic polyamines are essential for cell growth and differentiation, while polyamine analogues exert antitumor activity in multiple experimental model systems, including breast and lung cancer. Dendrimers are widely used for drug delivery in vitro and in vivo. We report the bindings of biogenic polyamines, spermine (spm), and spermidine (spmd), and their synthetic analogues, 3,7,11,15-tetraza...

2015
Łukasz Uram Magdalena Szuster Aleksandra Filipowicz Krzysztof Gargasz Stanisław Wołowiec Elżbieta Wałajtys-Rode

The intracellular localization and colocalization of a fluorescently labeled G3 amine-terminated cationic polyamidoamine (PAMAM) dendrimer and its biotin-pyridoxal (BC-PAMAM) bioconjugate were investigated in a concentration-dependent manner in normal human fibroblast (BJ) and squamous epithelial carcinoma (SCC-15) cell lines. After 24 hours treatment, both cell lines revealed different pattern...

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