1. Mithal A. Paget’s disease in India. J Assoc Physicians India 2006;54: 521-2. 2. Raubenheimer PJ, Taylor AG, Soule SG. Paget’s disease complicated by hydrocephalus and syringomyelia. Br J Neurosurg 2002;16: 513-6. 3. Dohrmann PJ, Elrick WL. Dementia hydrocephalus in Paget’s disease: A case report. J Neurol Neurosurg Psychiatry 1982;45:835-7. 4. Martin BJ, Roberts MA, Turner JW. Normal pressur...

Extramammary Paget disease of the vulva was found in association with vulval adenocarcinoma in an elderly woman who also had a uterine prolapse. The characteristic histological appearances of extramammary Paget disease were masked by striking reactive changes in the squamous epithelium. Primary excision of both the intraepithelial and invasive disease appeared complete. However, a subsequent hy...

Paget’s eponymous disease ensures that the name of Sir James Paget (1814–99) is known to all doctors and many patients. Specialists also know of Paget’s abscess, Paget’s disease of the nipple, Paget’s extramammary disease, Paget-von Schrötter syndrome, Paget’s recurrent desmoid tumour of the rectus sheath, Pagetoid epithelioma, juvenile Paget’s disease, and Paget’s quiet necrosis of bone, and t...

This case describes new onset mammary Paget disease arising in the background of Darier disease. Clinically and histologically, lesions of Darier disease can mask the lesions of mammary Paget disease. A high index of suspicion is necessary to diagnose Paget disease in a patient with Darier disease, for a potentially fatal disease could easily be missed.

Pigmented mammary Paget disease is a very rare clinicopathologic variant of mammary Paget disease. Diagnosis is often difficult because its clinical and histological features are very similar to those of malignant melanoma. Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma.

BACKGROUND Pigmented mammary Paget disease represents a rare variant of mammary Paget disease that clinically and dermoscopically simulates a melanoma. We report a case of pigmented mammary Paget disease mimicking a melanoma and describe the dermoscopic, reflectance-mode confocal microscopic, histological, and immunohistochemical features. OBSERVATIONS A 70-year-old woman had a 5.5x4-cm pigme...

Paget disease is a common bone disease characterized by abnormal osteoclasts that are large, multinucleated, and overactive and that contain paramyxovirus-like nuclear inclusions. There is evidence for a major genetic component to Paget disease, with up to 40% of patients having affected first-degree relatives; however, the locus (loci) and gene(s) involved are unknown. Another bone disorder, f...

Paget disease of bone is a common disorder affecting approximately 3%-4% of the population over 40 years of age. The pathologic abnormality in Paget disease is excessive and abnormal remodeling of bone. Three pathologic phases have been described: the lytic phase (incipient-active), in which osteoclasts predominate; the mixed phase (active), in which osteoblasts cause repair superimposed on the...

Extramammary Paget disease (EMPD) is an uncommon malignancy. It manifests either in the primary form in the skin as an intraepithelial neoplasm, or in secondary form as pagetoid (intraepithelial) spread of an underlying internal carcinoma to the skin. Although local invasion and recurrence of primary extramammary Paget disease are relatively frequent, widespread metastases are rare. As such, th...

By the use of a modified incubating medium, lactic dehydrogenase in Paget cells was histochemically examined. The addition of phenazine methosulfate to the substrate solution decreased the reaction intensity of lactic dehydrogenase in Paget cells. In the presence of potassium cyanide, however, phenazine methosulfate caused increased reaction. When urea was introduced into the substrate solution...