نتایج جستجو برای: p53 expression

تعداد نتایج: 898809  

Journal: Iranian Journal of Immunology 2004
Ahmad Monabati Nasser Gholijani Zahra Amirghofran,

Background: Prostate cancer is one of the most commonly diagnosed cancers in males. Tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. Objective: To investigate the expression of p53 protein and its relation to apoptosis and prostate cancer traditional prognostic indicators. Methods: In this study expression of p53 was examined in p...

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Journal: :iranian journal of immunology 0
nasser gholijani immunology and ahmad monabati pathology, medical school, shiraz university of medical sciences, shiraz, iran zahra amirghofran immunology and

background: prostate cancer is one of the most commonly diagnosed cancers in males. tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. objective: to investigate the expression of p53 protein and its relation to apoptosis and prostate cancer traditional prognostic indicators. methods: in this study expression of p53 was examined in p...

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Journal: International Journal of Molecular and Cellular Medicine 2013
Ali Bijani, Maryam Seyedmajidi, Nazanin Keshmiri, Sepideh Siadati, Shahryar Shafaee, Shima Nafarzadeh,

p53 and PCNA expression in keratocystic odontogenic tumors compared with selected odontogenic cysts Summary: The aim of this study was to evaluate p53 and PCNA expression in different odontogenic lesions regarding their different clinical behaviors. Slices prepared from 94 paraffin-embedded tissue blocks (25 radicular cysts (RC), 23 dentigerous cysts (DC), 23 keratocystic odontogenic tumors (KC...

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Journal: :acta medica iranica 0
hamed montazeri department of molecular biology, pasteur institute of iran, tehran, iran. saeid bouzari department of molecular biology, pasteur institute of iran, tehran, iran. kayhan azadmanesh department of virology, pasteur institute of iran, tehran, iran. seyed nasser ostad department of toxicology pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. mohammad hossein ghahremani department of toxicology-pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. and department of molecular medicine, school of advanced technology in medicine, tehran university of medical sciences, tehran, iran.

cyclin e, her-2 and p53, are considered as major prognostic markers in breast cancer. as they are related in patho-clinical level, we aimed to check if they have any direct interaction on expression of each other. to study the effect of cyclin e on her-2 expression, cell lines stably overexpressing cyclin e or its low molecular weight (lmw) isoforms were generated. to understand the results of ...

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ژورنال: Medical Laboratory Journal 2019
Emami Razavi , Amir Nader, Joshaghani , Hamidreza, Besharat , Sima , Salar Amoli , Sanaz, Shahin, Khashayar ,

Background and Objective: Breast cancer is the most commonly diagnosed cancer in women worldwide, which alone accounts for 30% of all new cancer cases in women. The development of cancer is a multistep process.  The complex series of cellular and molecular changes participating in cancer development are mediated by a diversity of stimuli such as Oxidative stress that is known to cause DNA damag...

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Journal: :gene, cell and tissue 0
zahra heidari non-communicable disease research center, zahedan university of medical sciences, zahedan, ir iran; department of histology, zahedan university of medical sciences, zahedan, ir iran hamidreza mahmoudzade sagheb non-communicable disease research center, zahedan university of medical sciences, zahedan, ir iran; department of histology, zahedan university of medical sciences, zahedan, ir iran azam asemi rad department of histology, zahedan university of medical sciences, zahedan, ir iran; department of histology, zahedan university of medical sciences, zahedan, ir iran. tel: +98-9153490301 mahmoud ali keikhaee department of internal medicine, zahedan university of medical sciences, zahedan, ir iran

background there is a potential risk for malignancy in patients with diabetes mellitus. theoretically, a noninvasive method for detection of precancerous changes can be conducted on oral exfoliated cell smears. objectives in this study, the immunocytochemistry of p53 in exfoliated oral mucosal cells in patients with type 2 diabetes was investigated. patients and methods oral mucosal smears were...

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ژورنال: مجله علمی دانشگاه علوم پزشکی همدان 2012
ترابیان, سعادت, عبدلی, عفت, راستگوی حقی, علیرضا ,

Introduction & Objective: Hodgkin lymphoma accounts for about 1% of all cancers. Cyclooxygenase 2 (COX2) is a cytoplasmic enzyme. Oncogene, and growth factor induce over expression of COX2. COX2 is apoptotic inhibitor. Mutation of the p53 tumor suppressor gene represents the most common genetic alternation in human tumors. This study aimed to evaluate the expression of COX2 and p53 in subtype...

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Journal: :iranian biomedical journal 0
مرضیه حقی شریفیا تقوی marzieh hagi-sharifia taghavi جمشید داوودی jamshid davoodi منوچهر میرشاهی manouchehr mirshahi

the p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. pancreatic tumor cells show a very high frequency of p53 mutation. to determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, panc-1 and htb80, differing in p53 status were stably transfected with exogenous wil...

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Journal: International Journal of Radiation Research 2015
F.Z. Tohidi, Gholamreza Anani Sarab, H. Azimian, M.H. Bahrayni Toosi, R. Fardid, S. Khademi,

Background:  Widespread and growing sources of electromagnetic radiation raised concerns attributed to the potential adverse health risk of radiofrequency fields. Given the functional importance of the hippocampus, this study aimed to investigate the effects of electromagnetic waves radiated by mobile jammer on hippocampal expression of p21 and p53 genes as regulators of cellular apoptosis...

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Journal: Iranian Biomedical Journal 2007
Jamshid Davoodi, Manouchehr Mirshahi, Marzieh Hagi-Sharifia Taghavi,

The p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. Pancreatic tumor cells show a very high frequency of p53 mutation. To determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, PANC-1 and HTB80, differing in p53 status were stably transfected with exogenous wil...

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