نتایج جستجو برای: p53 cells

تعداد نتایج: 1407387  

Journal: :iranian biomedical journal 0
مرضیه حقی شریفیا تقوی marzieh hagi-sharifia taghavi جمشید داوودی jamshid davoodi منوچهر میرشاهی manouchehr mirshahi

the p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. pancreatic tumor cells show a very high frequency of p53 mutation. to determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, panc-1 and htb80, differing in p53 status were stably transfected with exogenous wil...

Jamshid Davoodi, Manouchehr Mirshahi, Marzieh Hagi-Sharifia Taghavi,

The p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. Pancreatic tumor cells show a very high frequency of p53 mutation. To determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, PANC-1 and HTB80, differing in p53 status were stably transfected with exogenous wil...

The effect of p53 gene therapy on chemosensitivity and apoptotic response of PANC-1 tumor cells, which express high amount of mutant p53, to cancer chemotherapeutic agents of Etoposide and Doxorubicin was investigated. Comparison of the chemosensitivity of PANC-1 cells to its wild type p53 transfectants showed that wt-p53 expressing transfectants are more sensitive to both Etoposide and Doxorub...

      Curcumin is a natural substance with anti-cancerous properties without many disadvantages of currently-used anticancer drugs. Its toxicity is significantly higher in tumor cells compared with normal cells. We hypothesized the difference of p53 function between normal and tumor cells as one of the presumable causes of this phenomenon. We knocked down the expression of p53 in normal fibrobl...

Objective(s): Glioblastoma is the most lethal tumor of the central nervous system. Here, we aimed to evaluate the effects of exogenous delivery of p53 and a nanoformulation of curcumin called dendrosomal curcumin (DNC), alone and in combination, on glioblastoma tumor cells. Materials and Methods: MTT assay was exploited to measure the viability of U87-MG cells against DNC treatment. Cells were ...

Journal: :iranian journal of basic medical sciences 0
reihaneh keshavarz department of molecular genetics, faculty of biological sciences, tarbiat modares university, tehran, iran babak bakhshinejad department of molecular genetics, faculty of biological sciences, tarbiat modares university, tehran, iran sadegh babashah department of molecular genetics, faculty of biological sciences, tarbiat modares university, tehran, iran narges baghi department of molecular genetics, faculty of biological sciences, tarbiat modares university, tehran, iran majid sadeghizadeh department of molecular genetics, faculty of biological sciences, tarbiat modares university, tehran, iran

objective(s): glioblastoma is the most lethal tumor of the central nervous system. here, we aimed to evaluate the effects of exogenous delivery of p53 and a nanoformulation of curcumin called dendrosomal curcumin (dnc), alone and in combination, on glioblastoma tumor cells. materials and methods: mtt assay was exploited to measure the viability of u87-mg cells against dnc treatment. cells were ...

Journal: :gene, cell and tissue 0
zahra heidari non-communicable disease research center, zahedan university of medical sciences, zahedan, ir iran; department of histology, zahedan university of medical sciences, zahedan, ir iran hamidreza mahmoudzade sagheb non-communicable disease research center, zahedan university of medical sciences, zahedan, ir iran; department of histology, zahedan university of medical sciences, zahedan, ir iran azam asemi rad department of histology, zahedan university of medical sciences, zahedan, ir iran; department of histology, zahedan university of medical sciences, zahedan, ir iran. tel: +98-9153490301 mahmoud ali keikhaee department of internal medicine, zahedan university of medical sciences, zahedan, ir iran

background there is a potential risk for malignancy in patients with diabetes mellitus. theoretically, a noninvasive method for detection of precancerous changes can be conducted on oral exfoliated cell smears. objectives in this study, the immunocytochemistry of p53 in exfoliated oral mucosal cells in patients with type 2 diabetes was investigated. patients and methods oral mucosal smears were...

Journal: :biomacromolecular journal 2015
alemeh heidarzadeh ali mohammad ahadi alireza panahi majid sadeghizadeh

curcumin is a natural substance with anti-cancerous properties without many disadvantages of currently-used anticancer drugs. its toxicity is significantly higher in tumor cells compared with normal cells. we hypothesized the difference of p53 function between normal and tumor cells as one of the presumable causes of this phenomenon. we knocked down the expression of p53 in normal fibroblasts u...

Journal: :Applied sciences 2022

Background: Mutation of p53 is a frequent event, and mutant exhibits low levels acetylation phosphorylation. This study aimed to investigate the effect histone deacetylase (HDAC) inhibitor, 4-hexylresorcinol (4HR), on phosphorylation carcinoma cells its therapeutic effects in xenograft model. Methods: To determine 4HR p53, western blot analysis was performed using YD-9 YD-15 cells. siRNA used e...

Journal: :research in pharmaceutical sciences 0
mehdi nikbakht dastjerdi mohammad zamani rarani ali valiani mohsen mahmoudieh

adenosine receptor family especially a1 type is expressed in breast cancer cells in which p53 and caspase genes are wild-type. the aim of this study was to investigate the correlation between a1 receptor and either cell apoptosis or proliferation and also to recognize the relationship between this receptor and p53 and the expression of caspases 3, 8 and 9 in mcf-7 cell line. mcf-7 cells were tr...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید