نتایج جستجو برای: p5 peptide

تعداد نتایج: 161329  

The purpose of this study was to optimize a method for the encapsulation of P5 peptide, a new designed peptide containing MHC class I epitopes from rat HER2/neu protein, into liposomes as an approach for breast cancer vaccine formulation. The efficiency of liposomal encapsulation of peptides is generally low and development of an optimized method to increase encapsulation efficiency is a big ch...

The purpose of this study was to optimize a method for the encapsulation of P5 peptide, a new designed peptide containing MHC class I epitopes from rat HER2/neu protein, into liposomes as an approach for breast cancer vaccine formulation. The efficiency of liposomal encapsulation of peptides is generally low and development of an optimized method to increase encapsulation efficiency is a big ch...

Journal: :iranian journal of pharmaceutical research 0
sheyda shariat department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran ali badiee nanotechnology research center,school of pharmacy, mashhad university of medical sciences, mashhad, iran mahmoud reza jaafari biotechnology research center, nanotechnology research center ,school of pharmacy, mashhad university of medical sciences, mashhad, iran seyed alireza mortazavi department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran

the purpose of this study was to optimize a method for the encapsulation of p5 peptide, a new designed peptide containing mhc class i epitopes from rat her2/neu protein, into liposomes as an approach for breast cancer vaccine formulation. the efficiency of liposomal encapsulation of peptides is generally low and development of an optimized method to increase encapsulation efficiency is a big ch...

Ali Badiee Mahmoud Reza Jaafari, Mercedeh Mansourian Seyed Alireza Mortazavi, Seyed Amir Jalali, Sheida Shariat

Objective(s):Tumor-associated antigen (TAA) subunit-based vaccines constitute promising tools for anticancer immunotherapy. However, a major limitation in the development of such vaccines is the poor immunogenicity of peptides when used alone.The aim of this study was to develop an efficient vaccine delivery system and adjuvant to enhance anti-tumor activity of a synthetic HER2/neu derived pept...

Journal: :iranian journal of basic medical sciences 0
sheida shariat department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran ali badiee nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran seyed amir jalali department of immunology, medical school, shahid beheshti university of medical sciences, tehran, iran mercedeh mansourian nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran seyed alireza mortazavi department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran mahmoud reza jaafari biotechnology research center, nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s):tumor-associated antigen (taa) subunit-based vaccines constitute promising tools for anticancer immunotherapy. however, a major limitation in the development of such vaccines is the poor immunogenicity of peptides when used alone.the aim of this study was to develop an efficient vaccine delivery system and adjuvant to enhance anti-tumor activity of a synthetic her2/neu derived pept...

2015
B.K. Binukumar Varsha Shukla Niranjana D. Amin Manju Bhaskar Suzanne Skuntz Joseph Steiner Dirk Winkler Steven L. Pelech Harish C. Pant

Besides the hallmark pathology of amyloid plaques and neurofibrillary tangles, it is well documented that cyclin-dependent kinase 5 (CDK5), a critical neuronal protein kinase in nervous system development, function, and survival, when deregulated and hyperactivated induces Alzheimer's disease (AD) and amyotrophic lateral sclerosis and Parkinson's disease-like phenotypes in mice. In a recent stu...

2016
Jonathan S. Wall Angela Williams Craig Wooliver Emily B. Martin Xiaolin Cheng R. Eric Heidel Stephen J. Kennel

BACKGROUND Polybasic helical peptides, such as peptide p5, bind human amyloid extracts and synthetic amyloid fibrils. When radiolabeled, peptide p5 has been shown to specifically bind amyloid in vivo thereby allowing imaging of the disease. Structural requirements for heparin and amyloid binding have been studied using analogs of p5 that modify helicity and chirality. METHODS Peptide-ligand i...

2014
Sheyda Shariat Ali Badiee Mahmoud Reza Jaafari Seyed Alireza Mortazavi

The purpose of this study was to optimize a method for the encapsulation of P5 peptide, a new designed peptide containing MHC class I epitopes from rat HER2/neu protein, into liposomes as an approach for breast cancer vaccine formulation. The efficiency of liposomal encapsulation of peptides is generally low and development of an optimized method to increase encapsulation efficiency is a big ch...

2013
Jonathan S. Wall Angela Williams Tina Richey Alan Stuckey Ying Huang Craig Wooliver Sallie Macy Eric Heidel Neil Gupta Angela Lee Brianna Rader Emily B. Martin Stephen J. Kennel

Amyloid is a complex pathology associated with a growing number of diseases including Alzheimer's disease, type 2 diabetes, rheumatoid arthritis, and myeloma. The distribution and extent of amyloid deposition in body organs establishes the prognosis and can define treatment options; therefore, determining the amyloid load by using non-invasive molecular imaging is clinically important. We have ...

2015
Sheida Shariat Ali Badiee Seyed Amir Jalali Mercedeh Mansourian Seyed Alireza Mortazavi Mahmoud Reza Jaafari

OBJECTIVES Tumor-associated antigen (TAA) subunit-based vaccines constitute promising tools for anticancer immunotherapy. However, a major limitation in the development of such vaccines is the poor immunogenicity of peptides when used alone. The aim of this study was to develop an efficient vaccine delivery system and adjuvant to enhance anti-tumor activity of a synthetic HER2/neu derived pepti...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید