نتایج جستجو برای: p2x3

تعداد نتایج: 460  

Journal: :Journal of molecular cell biology 2014
Xu-Qiao Chen Jing-Xiang Zhu Yan Wang Xu Zhang Lan Bao

The P2X3 receptor plays a vital role in sensory processing and transmission. The assembly and trafficking of the P2X3 receptor are important for its function in primary sensory neurons. As an important inflammation mediator, ATP is released from different cell types around primary sensory neurons, especially under pathological pain conditions. Here, we show that α, β-MeATP dramatically promoted...

2015
Anna Marchenkova Sandra Vilotti Elsa Fabbretti Andrea Nistri

BACKGROUND ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons. In mouse trigeminal ganglion (TG), P2X3 receptor function is unexpectedly enhanced by pharmacological block of natriuretic peptide receptor-A (NPR-A), outlining a potential inhibitory role of endogenous natriuretic peptides in nociception mediate...

Journal: :Molecular pharmacology 2013
Gary Mo Jennifer C Peleshok Chang-Qing Cao Alfredo Ribeiro-da-Silva Philippe Séguéla

Purinergic signaling contributes significantly to pain mechanisms, and the nociceptor-specific P2X3 ATP receptor channel is considered a target in pain therapeutics. Recent findings suggesting the coexpression of metabotropic P2Y receptors with P2X3 implies that ATP release triggers the activation of both ionotropic and metabotropic purinoceptors, with strong potential for functional interactio...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Alexandre Serrano Gary Mo Rebecca Grant Michel Paré Dajan O'Donnell Xiao Hong Yu Miroslaw J Tomaszewski Martin N Perkins Philippe Séguéla Chang Qing Cao

Evidence suggesting the involvement of P2X2 and P2X3 in chronic pain has been obtained mostly from rodent models. Here we show that rodents may be poor predictors of P2X3 pharmacology in human. We demonstrate that monkey and human dorsal root ganglion (DRG) neurons do not express appreciable levels of P2X2 subunit, contrary to rat sensory neurons. Additionally, we report functional P2X3 activit...

Journal: :Autonomic neuroscience : basic & clinical 2008
Yunxia Wang Guiling Li Shangdong Liang Aixia Zhang Changshui Xu Yun Gao Chunping Zhang Fang Wan

Extracellular ATP acts on purinergic receptors as a potent agonist for a variety of different cell types, including cardiomyocytes and nodose ganglia. P2X3 receptor is the most abundant P2X-receptor subtype in heart and nodose ganglia. This study wants to observe the role of P2X3 receptor in myocardial ischemic injury and nociceptive transmission via nodose ganglia. The serum lactate dehydrogen...

2013
Gary Mo Jennifer C. Peleshok Chang-Qing Cao Alfredo Ribeiro-da-Silva Philippe Séguéla Alan Edwards

Purinergic signaling contributes significantly to pain mechanisms, and the nociceptor-specific P2X3 ATP receptor channel is considered a target in pain therapeutics. Recent findings suggesting the coexpression of metabotropic P2Y receptors with P2X3 implies that ATP release triggers the activation of both ionotropic and metabotropic purinoceptors, with strong potential for functional interactio...

2011
E. Pryazhnikov D. Fayuk M. Niittykoski Rashid Giniatullin Leonard Khiroug

ATP-gated P2X3 receptors are expressed by nociceptive neurons and participate in transduction of pain. Responsiveness of P2X3 receptors is strongly reduced at low temperatures, suggesting a role for these receptors in analgesic effects of cooling. Since sustained responsiveness depends on receptor trafficking to the plasma membrane, we employed total internal reflection fluorescence (TIRF) micr...

Journal: :The Journal of physiology 2005
Debra A Cockayne Philip M Dunn Yu Zhong Weifang Rong Sara G Hamilton Gillian E Knight Huai-Zhen Ruan Bei Ma Ping Yip Philip Nunn Stephen B McMahon Geoffrey Burnstock Anthony P D W Ford

Extracellular ATP plays a role in nociceptive signalling and sensory regulation of visceral function through ionotropic receptors variably composed of P2X2 and P2X3 subunits. P2X2 and P2X3 subunits can form homomultimeric P2X2, homomultimeric P2X3, or heteromultimeric P2X2/3 receptors. However, the relative contribution of these receptor subtypes to afferent functions of ATP in vivo is poorly u...

2013
Swathi K. Hullugundi Michel D. Ferrari Arn M. J. M. van den Maagdenberg Andrea Nistri

A knock-in (KI) mouse model of FHM-1 expressing the R192Q missense mutation of the Cacna1a gene coding for the α1 subunit of CaV2.1 channels shows, at the level of the trigeminal ganglion, selective functional up-regulation of ATP -gated P2X3 receptors of sensory neurons that convey nociceptive signals to the brainstem. Why P2X3 receptors are constitutively more responsive, however, remains unc...

Journal: :Journal of dental research 2001
A M Alavi G R Dubyak G Burnstock

Evidence is accumulating which supports a role for ATP in the initiation of pain by acting on P2X receptors, in particular P2X3, expressed on nociceptive afferent nerve terminals. To investigate whether this receptor plays a role in dental pain, we studied the presence and distribution of P2X3 receptors in human dental pulp, and their co-localization with other neural markers. Pulps were remove...

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