نتایج جستجو برای: p234

تعداد نتایج: 42  

Journal: :Reproduction 2015
Zafer Sahin Sinan Canpolat Mete Ozcan Tuba Ozgocer Haluk Kelestimur

The aim of this study was to determine the modulatory effects of peptide 234 (p234) (an antagonist of GPR54 receptors) on kisspeptin and RF9 (an RFamide-related peptide antagonist)-induced changes in reproductive functions and energy balance in female rats. Female Sprague-Dawley rats were weaned on postnatal day (pnd) 21. The animals were intracerebroventricularly cannulated under general anest...

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2014
Fariba Mahmoudi Homayoun Khazali Mahyar Janahmadi

BACKGROUND Kisspeptin-GPR54 system stimulates the hypothalamus-pituitary-gonadal (HPG) axis; dysfunction of the gene encoding the GPR54 receptor causes hypogonadism and infertility. Opioid peptides inhibit the reproductive axis. Peptide 234 is a GPR54 receptor antagonist and blocks the stimulatory effects of kisspeptin on HPG axis. OBJECTIVES Interactions of morphine, kisspeptin and peptide 2...

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Journal: :international journal of endocrinology and metabolism 0
fariba mahmoudi department of animal sciences,faculty of biological sciences, shahid beheshti university, tehran, ir iran homayoun khazali department of animal sciences,faculty of biological sciences, shahid beheshti university, tehran, ir iran; department of animal sciences,faculty of biological sciences, shahid beheshti university, tehran, ir iran. tel: +98-9121254041 mahyar janahmadi department of phsiology neurophysiology research center, medical school, shahid beheshti university of medical sciences, tehran, ir iran

background: kisspeptin-gpr54 system stimulates the hypothalamus-pituitary-gonadal (hpg) axis; dysfunction of the gene encoding the gpr54 receptor causes hypogonadism and infertility. opioid peptides inhibit the reproductive axis. peptide 234 is a gpr54 receptor antagonist and blocks the stimulatory effects of kisspeptin on hpg axis. objectives: interactions of morphine, kisspeptin and peptide 2...

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2017
C H J Albers-Wolthers J de Gier M Walen P J S van Kooten C B Lambalk P A J Leegwater B A J Roelen A C Schaefers-Okkens V P M G Rutten R P M Millar H S Kooistra

Kisspeptins (KPs) and their receptor (GPR54 or KiSS1R) play a key-role in regulation of the hypothalamic-pituitary-gonadal axis and are therefore interesting targets for therapeutic interventions in the field of reproductive endocrinology. As dogs show a rapid and robust LH response after the administration of KP10, they can serve as a good animal model for research concerning KP signaling. The...

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Journal: International Journal of Fertility and Sterility 2018
Fariba Mahmoudi, Homayoun Khazali, Mahyar Janahmadi,

Objective The inhibitory effects of Morphine and the stimulatory influence of kisspeptin signaling have been demonstrated on GnRH/LH release. Hypothalamic kisspeptin is involved in relaying the environmental and metabolic information to reproductive axis. In the present study the role of kisspeptin/GPR54 signaling system was investigated on relaying the inhibitory effects of morphine on LH horm...

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Journal: :Thorax 2015

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2017
Kengo Sato Remina Shirai Mina Hontani Rina Shinooka Akinori Hasegawa Tomoki Kichise Tomoyuki Yamashita Hayami Yoshizawa Rena Watanabe Taka‐aki Matsuyama Hatsue Ishibashi‐Ueda Shinji Koba Youichi Kobayashi Tsutomu Hirano Takuya Watanabe

BACKGROUND Kisspeptin-10 (KP-10), a potent vasoconstrictor and inhibitor of angiogenesis, and its receptor, GPR54, have currently received much attention in relation to pre-eclampsia. However, it still remains unknown whether KP-10 could affect atherogenesis. METHODS AND RESULTS We evaluated the effects of KP-10 on human umbilical vein endothelial cells, human monocyte-derived macrophages, hu...

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Journal: :Journal of Crohn's and Colitis 2009

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Journal: :Antimicrobial Resistance and Infection Control 2013

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Journal: :Thorax 2016

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