The transition of microtubules (MTs) from an assembled to a disassembled state plays an essential role in several cellular functions. While MT dynamics are often linked to those of actin filaments, little is known about whether intermediate filaments (IFs) have an influence on MT dynamics. We show here that plectin 1c (P1c), one of the multiple isoforms of the IF-associated cytolinker protein p...

BACKGROUND Antiplatelet therapy plays a pivotal role in the prevention and treatment of thrombotic diseases. We reported the screening of P1C as a novel integrin-binding peptide from the C-terminal of connective tissue growth factor. Primary study indicated that P1C has potential against platelet aggregation. OBJECTIVES We aimed to find the shortest active unit from the P1C fragments and expl...

the superiority of the quadratic images to second harmonic (SH) images in phantoms, both in terms of spatial and contrast resolutions. Furthermore, we have shown that the quadratic images produce contrast-to-tissue ratios (CTRs) at the same level of those produced by pulse inversion (PI) without the need for multiple transmission. The imaging results have also shown that quadratic imaging also ...

The mouse NK1.1 Ag originally defined as NK cell receptor (NKR)-P1C (CD161) mediates NK cell activation. Here, we show that another member of the mouse CD161 family, NKR-P1B, represents a novel NK1.1 Ag. In contrast to NKR-P1C, which functions as an activating receptor, NKR-P1B inhibits NK cell activation. Association of NKR-P1B with Src homology 2-containing protein tyrosine phosphatase-1 prov...

Cytolinker proteins stabilize cells mechanically, regulate cytoskeleton dynamics, and provide scaffolds for signaling molecules. For plectin, the prototype of these proteins, an unusual diversity of isoforms has been reported, which show distinct expression patterns, subcellular localizations, and functions. Plectin has been shown to have important functions in skin and muscle, but little is kn...

To assess the maternal and neonatal risk associated with high order cesarean sections, a prospective study was carried out in Zawia hospital, maternity wards. The patient was interviewed in the labor word and performed case sheet filled with specific data. The outcome of 458 cases, 218 women undergoing cesarean section for the third time or more was compared with 240 women sectioned for the sec...

The proximal region of the NK gene complex encodes the NKR-P1 family of killer cell lectin-like receptors which in mice bind members of the genetically linked C-type lectin-related family, while the distal region encodes Ly49 receptors for polymorphic MHC class I molecules. Although certain members of the NKR-P1 family are expressed by all NK cells, we have identified a novel inhibitory rat NKR...

BACKGROUND AND PURPOSE Intravital imaging provides invaluable readouts for clinical diagnoses and therapies and shows great potential in the design of individualized drug dosage regimes. Ts is a mammalian free cell membrane-penetrating peptide. This study aimed to introduce a novel approach to the design of a cancer-selective peptide on the basis of a membrane-penetrating peptide and to explore...

Serum C3 (P1C/PIA) has been measured in normal individuals and the range found is in agreement with findings of other authors (85-370 mg/100 ml). In 18 patients with acute hepatitis and massive necrosis serum C3 was consistently reduced to below 50% of normal. In other patients with acute hepatitis the serum C3 concentration was normal. In the majority of the 150 patients with chronic liver dis...

We study the action of the absolute Galois group Gal(Q̄/Q) on the algebraic fundamental group of P1C\{0, 1,∞}. We define a class of functions called Belyi-extending maps, and using them we are able to (1) give new Galois invariants of Grothendieck’s dessins d’enfants and (2) give explicit relations on the fσ in terms of which the Galois action on π̂1(P 1 C \ {0, 1,∞}) is known.