نتایج جستجو برای: p17 antigen

تعداد نتایج: 200845  

Journal: :Clinical and diagnostic laboratory immunology 2000
S Hashida S Ishikawa K Hashinaka I Nishikata S Oka E Ishikawa

For earlier diagnosis of human immunodeficiency virus type 1 (HIV-1) infection, the sensitivities of immune complex transfer enzyme immunoassays for HIV-1 p24 antigen and antibody immunoglobulin G (IgG) to HIV-1 p17 antigen were improved approximately 25- and 90-fold, respectively, over those of the previous immunoassays by performing solid-phase immunoreactions with shaking and increasing the ...

Journal: :Memorias do Instituto Oswaldo Cruz 2006
Gema Alvarez García Inmaculada López Pérez Elisabeth Innes Esther Collantes Fernandez Aurora Fernandez Garcia Mercedes Gomez Bautista Luis Miguel Ortega Mora

A Neospora caninum 17 kDa protein fraction (p17) has been described as an immunodominant antigen (IDA) under reducing and non-reducing conditions. The aim of the present study was to investigate the diagnostic utility of p17 in cattle. In order to achieve this, p17 was purified by electroelution from whole N. caninum tachyzoite soluble extract and a p17-based Western blot (WB-p17) was developed...

Journal: :Journal of virology 2002
W M Cohen A Bianco F Connan L Camoin M Dalod G Lauvau E Ferriès B Culmann-Penciolelli P M van Endert J P Briand J Choppin J G Guillet

Cytotoxic T-lymphocyte (CTL) responses directed to different human immunodeficiency virus (HIV) epitopes vary in their protective efficacy. In particular, HIV-infected cells are much more sensitive to lysis by anti-Gag/p17(77-85)/HLA-A2 than to that by anti-polymerase/RT(476-484)/HLA-A2 CTL, because of a higher density of p17(77-85) complexes. This report describes multiple processing steps fav...

Journal: :Genitourinary medicine 1988
P Van de Perre A De Clercq J Cogniaux-Leclerc D Nzaramba J P Butzler S Sprecher-Goldberger

Human immunodeficiency virus (HIV) has been isolated from cervicovaginal secretions from infected women and is thought to be cell associated. To identify which cells harbour viral antigen, we used monoclonal antibodies to OKT4 and a monoclonal antibody directed against HIV p17 core antigen to perform indirect immunofluorescence assays of genital secretions from 17 HIV seropositive and 17 HIV se...

2010
Kuntida Kitidee Sawitree Nangola Gaëlle Gonzalez Pierre Boulanger Chatchai Tayapiwatana Saw-See Hong

BACKGROUND Cells permissive to virus can become refractory to viral replication upon intracellular expression of single chain fragment variable (scFv) antibodies directed towards viral structural or regulatory proteins, or virus-coded enzymes. For example, an intrabody derived from MH-SVM33, a monoclonal antibody against a conserved C-terminal epitope of the HIV-1 matrix protein (MAp17), was fo...

Journal: :Virology 2010
Antonella Caivano Nicole A Doria-Rose Benjamin Buelow Rossella Sartorius Maria Trovato Luciana D'Apice Gonzalo J Domingo William F Sutton Nancy L Haigwood Piergiuseppe De Berardinis

We have constructed stable virus-like particles displaying the HIV-1 Gag(p17) protein as an N-terminal fusion with an engineered protein domain from the Geobacillus stearothermophilus pyruvate dehydrogenase subunit E2. Mice immunized with the Gag(p17)-E2 60-mer scaffold particles mounted a strong and sustained antibody response. Antibodies directed to Gag(p17) were boosted significantly with ad...

So far, recombinant antigens of HIV-1, the etiologic cause of Acquired Immunodeficiency Syndrome (AIDS), have been widely used for the diagnosis and vaccine development. P17 or the matrix protein formed by the proteolytic cleavage of gag is strongly antigenic and is as conserved and immunogenic as p24. In some cases, antibodies to p17 are more prevalent than antibodies to p24 and the decline in...

2013
Panthip Tue-ngeun Kanchanok Kodchakorn Piyarat Nimmanpipug Narin Lawan Sawitree Nangola Chatchai Tayapiwatana Noorsaadah Abdul Rahman Sharifuddin Md. Zain Vannajan Sanghiran Lee

Computational approaches have been used to evaluate and define important residues for protein-protein interactions, especially antigen-antibody complexes. In our previous study, pairwise decomposition of residue interaction energies of single chain Fv with HIV-1 p17 epitope variants has indicated the key specific residues in the complementary determining regions (CDRs) of scFv anti-p17. In this...

Journal: :The Journal of Experimental Medicine 1997
Suzana Marusic Susumu Tonegawa

Experimental autoimmune encephalomyelitis (EAE), a demyelinating disease of the central nervous system, is an animal model of paralyzing human disease, multiple sclerosis. EAE is readily induced by immunization with myelin basic protein (MBP) in mice transgenic for an alphabeta T cell receptor (TCR) that is specific for MBP. Subcutaneous injection of p17 (a peptide consisting of 17 NH2-terminal...

Journal: :Journal of Microbiology, Biotechnology and Food Sciences 2017

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