نتایج جستجو برای: p14
تعداد نتایج: 1415 فیلتر نتایج به سال:
We report here the effect of increased amount a water-immiscible ionic liquid (IL), 1-butyl-1-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide (P14-TFSI), enhancing production paclitaxel with in situ extraction from an aqueous medium plant cell culture. The productivity culture including IL 10 vol% was 1.5 times greater than that 2.5 vol%. Moreover, addition elicitor, methyl jasmonate (MJ...
زمینه: افزایش متیلاسیون در جزایر CpG، یکی از مکانیسم‌های مهم در خاموش شدن ژن می‌باشد. در بسیاری از سرطان‌ها، ژن‌های مختلفی دچار این (CpG island hyper methylation) CIHM می‌گردند. فاکتور تنظیمی P14/ARF در تنظیم منفی سیکل سلولی از طریق تأثیر بر مسیر فاکتور P53 دخالت دارد. از طرف دیگر اینترلوکین 17 با اثرات التهابی می‌تواند باعث افزایش متیلاسیون گردد. هدف از این تحقیق بررسی متیلاسیون پرومتر ژن P14/...
The p14(ARF) protein directly inhibits the MDM-2 oncoprotein, which mediates degradation of the p53 protein. It has been shown that p14(ARF) expression is frequently down-regulated by p14(ARF) gene hypermethylation in colorectal cancer. To determine whether p14(ARF) inactivation was involved in ulcerative colitis (UC)-associated carcinogenesis, the frequency and timing of p14(ARF) methylation w...
The p14 subunit of the essential splicing factor 3b (SF3b) can be cross-linked to the branch-point adenosine of pre-mRNA introns within the spliceosome. p14 stably interacts with the SF3b subunit SF3b155, which also binds the 65-kDa subunit of U2 auxiliary splicing factor (U2AF65). We combined biochemical and NMR techniques to study the conformation of p14 either alone or complexed with SF3b155...
The INK4a/ARF locus encodes two distinct tumor suppressors, p16 and p14. Although the contribution of p16 to human tumorigenesis through point mutation, deletion, and hypermethylation has been widely documented, little is known about specific p14 lesions and their consequences. Recent data indicate that p14 suffers inactivation by promoter hypermethylation in colorectal cancer cells. Because it...
The p14/MP1 scaffold complex binds MEK1 and ERK1/2 on late endosomes, thus regulating the strength, duration and intracellular location of MAPK signaling. By organelle proteomics we have compared the protein composition of endosomes purified from genetically modified p14⁻/⁻, p14+/⁻ and p14(rev) mouse embryonic fibroblasts. The latter ones were reconstituted retrovirally from p14⁻/⁻ mouse embryo...
The INK4a/ARF locus encodes two cell cycle-regulatory proteins, p16 and p14, which share an exon using different reading frames. p14 antagonizes MDM2-dependent p53 degradation. However, no point mutations in p14 not altering p16 have been described in primary tumors. We report that p14 is epigenetically inactivated in several colorectal cell lines, and its expression is restored by treatment wi...
Overexpression of E2F-1 induces apoptosis by both a p14-p53and a p73-mediated pathway. p14 is the alternate tumor suppressor product of the INK4a/ARF locus that is inactivated frequently in lung carcinogenesis. Because p14 stabilizes p53, it has been proposed that the loss of p14 is functionally equivalent to a p53 mutation. We have tested this hypothesis by examining the genomic status of the ...
Inactivation of the ARF-p53 tumor suppressor pathway leads to immortalization of murine fibroblasts. The role of this pathway in immortalization of human epithelial cells is not clear. We analyzed the functionality of the p14(ARF)-p53 pathway in human mammary epithelial cells (MEC) immortalized by human papillomavirus 16 (HPV16) E6, the p53 degradation-defective E6 mutant Y54D, or hTERT. E6-MEC...
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