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the life cycle of the american trypanosome, trypanosoma rangeli, in its invertebrate host, rhodnius prolixus, is completed by invasion into the insect salivary glands. as a prerequisite, there is an initial recognition of the salivary gland receptors for the adhesion/invasion by t rangeli. therefore, the purpose of this study was to investigate the putative receptor molecules on either the sali...

NUCLEAR R1BONUCLEOPROTEIN PA TICLES .................................................................... 461 Evidence for, and lsolation of, hnRNP Particles ....................................................... 461 General Structural Features of hnRNP articles ...................................................... 467 Proteins of hnRNP Particles ..................................................

P roteins interact with each other in a highly specific manner, and protein interactions play a key role in many cellular processes; in particular, the distortion of protein interfaces may lead to the development of many diseases. To understand the mechanisms of protein recognition at the molecular level and to unravel the global picture of protein interactions in the cell, different experiment...

We have isolated 18S RNA from cytoplasmic extracts of Newcastle disease virus-infected Chinese hamster ovary cells and tested its ability to direct protein synthesis in extracts derived from wheat germ. The products of the cell-free reaction directed by this RNA contain polypeptides that comigrate with NP, M,F, and 47K roteins from virions. In addition, the products contain a polypeptide (67K) ...

It has been nearly 130 years since Sydney Ringer’s astute observations on the indispensability of extracellular Ca to eart muscle contraction (1). At the cellular level, we now now that fluctuations of cytosolic Ca are coordinated by everal myocyte proteins in order to functionally couple the ardiac action potential to sarcomeric shortening and mitohondrial energy production. This elegant myoca...

The sessile nature of plants enforces highly adaptable strategies to adapt different environmental stresses. Plants respond these stresses by a massive reprogramming mRNA metabolism. Balancing fates, including translation, sequestration, and decay is essential for not only coordinate growth development but also combat biotic abiotic RNA stress granules (SGs) processing bodies (P bodies) synchro...

Regulation of growth and development is controlled by the interactions of cells with each other and the extracellular environment through signal transduction pathways that control the differentiation process by stimulating proliferation or causing cell death. This review will define the common signaling molecules and provide an overview of the general principles of signal transduction events. W...

s e f o ne of the most important recent advances in our undertanding of the basic mechanisms of genetic cardiac disease as been the central role played by mutations in structural roteins. Nearly 2 decades ago Geisterfer-Lowrance et al. 1) published the first linkage of a mutation in the betayHC gene to hypertrophic cardiomyopathy (HCM). Since hat seminal finding, mutations in a broad array of p...

JCB • VOLUME 169 • NUMBER 1 • 2005 16 Folding in a crowd roteins fold better in a crowd, as predicted by a biophysical model from Margaret Cheung, Dmitri Klimov, and D. Thirumalai (University of Maryland, College Park, MD). Interactions between a protein and large nearby molecules produce repulsive forces at distances that can be as large as the protein itself. The group modeled the energetic e...