Parasites of the genus Leishmania are transmitted by sandflies that ingest the parasite in the amastigote stage resident within macrophages, then inoculate the promastigote stage into other hosts. Peganum harmala, or Syrian Rue, has pharmacologically active compounds including several alkaloids with antiprotozoal properties, which are found especially in the seeds and the roots. In this researc...

OBJECTIVE Peganum harmala (P. harmala), "Espand" in Persian, has small seeds and has been used in traditional medicine as emmenagogue and an abortifacient. It has various pharmacological effects such as antifungal, antibacterial, hypothermic, anticancer, antinociceptive, and reversible monoamine oxidase inhibition. CASE DETAILS This case was a 45 years old woman who ingested about 50 grams se...

Peganum harmala and Piper longum medicinal herbs are used in traditional medicine to treat various diseases and to relieve tragic processes. The chemical composition of these two compounds is their analgesic agent. The purpose of this study was the Peganum harmala and Piper longum rubbing oil effect on pain in male mice by using formalin test. In this study, male mice were divided into three gr...

BACKGROUND Leishmaniasis is one of the six most common parasitic infections in the tropical regions. There are different therapeutic modalities, however therapeutic resistance is developed and resulted in numerous problems. Therefore, evaluation of other therapeutic modalities is performed extensively. OBJECTIVES The current study aimed to compare the therapeutic response of cutaneous leishma...

The western flower thrips, Frankliniella occidentalis (Pergande) attacks a large number of crop plants. The current insecticides have caused resistance in insects and have caused outbreaks of thrips. In many instances, alternative methods of insect management and natural products, offer adequate pest control and pose fewer hazards. Several species of minute pirate bugs of the genus Orius play a...

Introduction: Benign prostatic hyperplasia (BPH) is considered as a major cause of lower urinary tract symptoms (LUTS) in older men and its most common sign is nocturia. Objectives: This study aimed to determine the effect of the seeds of Peganum harmala compared with tamsulosin on alleviating urinary symptoms in patients with BPH. Patients and Methods: In this single blind clinical trial study...

Alkaloids with allelopathic activity are not as well-known as other allelochemicals. Our study revealed that total alkaloids from seeds of the medicinal plant Peganum harmala L. possessed significant growth inhibitory effect on four treated plants, with dicot plants (lettuce and amaranth) being more sensitive than the tested monocot plants (wheat and ryegrass). Further investigation led to the ...

PURPOSE Peganum harmala L. (Zygophyllaceae) seeds extract is one of the main components of an ethnobotanical preparation used in the treatment of neoplasms in Iran. Cytotoxic effects of P. harmala extract on cancerous cell-lines have been reported before. beta-carbolines like harmaline and harmine are the major alkaloids present in the seeds of the P. harmala. Considering reports concerning DNA...

BACKGROUND In vitro and in vivo antileishmanial activities of crude hydroalcoholic extract of peganum harmala seeds were investigated against Leishmania major. METHODS The extract of aerial parts of P harmala was obtained by maceration. The in vitro experiments were performed on promastigotes to assess antileishmanial activity of the extract using amphotericin B as a reference. The in vivo st...

objective: addiction, especially morphine dependence is a prevalence and incurable disease. with regard to low ability of new chemical drugs in treatment of addicted ones and with respect to herbal medicine recommendation due to lower side effects and cheap production. this study experimentally examined the effect of p.harmala on morphine withdrawal syndrome. materials and methods: animals wer...