accumulating evidence suggest that in patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. to evaluate the association of oxidized low- density lipoprotein (ox-ldl) with the development of diabetic nephropathy, plasma level of ox-ldl were measured in 70 diabetic patients with macro and 63...

background: vascular calcification is an important stage in atherosclerosis. during this stage, vascular smooth muscle cells (vsmc) synthesize many osteogenic factors such as osteonectin (encoded by sparc). oxidative stress plays a critical role in atherosclerosis progression, and its accumulation in the vascular wall stimulates the development of atherosclerosis and vascular calcification. the...

osteonectin is a bone- associated protein involved in vascular calcification. adiponectin may protect against cardiovascular disease but possible effects on vascular calcification have been poorly studied. the aim of this study was to investigate the modulatory effect of adiponectin on oxidized low density lipoprotein (oxldl)- induced expression of osteonectin in human aorta vascular smooth mus...

background: there is evidence that cd36 promotes foam cell formation through internalizing oxidized ldl (ox-ldl) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. in addition, cd36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (ppar-γ). the aim of the present study was to evaluate and compare the effect of ...

background: elevated serum levels of oxidized low-density lipoprotein (oxldl) have been found in type 2 and in poorly controlled diabetic patients. gestational diabetes mellitus (gdm) has common features with type 2 diabetes. objective: the aim of our study was to evaluate the serum levels of oxldl in women with gdm compared to normal pregnant women. materials and methods: in this cross-section...

objective(s) oxidized low-density lipoproteins (ox-ldls) appear to play a significant role in atherogenesis. in fact, circulating ox-ldl concentrations have been recognized as a risk factor for cardiovascular disease (cvd). the main objectives of this study were to assess the effects of antioxidant vitamins on ox-ldl as a biomarker of cvd in male subjects with cvd risk factors. materials and me...

The influence of dietary oxidized oil was studied on laying hen performance, egg quality and blood metabolites.  Experiment was conducted on 160 laying hens (Hy-Line W-36, 54-61 wk of age) in a completely randomized design with five treatments and four replicated cages containing eight birds per cage. Dietary treatments replaced fresh soybean oil in the control diet (3% fresh soybean oil, 15.25...

The direct vasoactive effects of native and oxidatively modified low density lipoproteins as well as their effects on endothelium-dependent relaxations to 5-hydroxytryptamine were studied in isolated rings of pig right coronary artery. Slowly developing contractions were caused by native low density lipoproteins (100 gg protein/ml). The contractions were more pronounced in the absence than in t...