نتایج جستجو برای: oxidative deamination

تعداد نتایج: 129895  

Journal: :modares journal of medical sciences: pathobiology 2007
yasamin danaee mehrdad behmanesh majid sadeghizadeh

objective: the itpa gene is responsible to remove free deaminated purine nucleotides of itp, ditp and xtp from nucleotide pool of the cells. it seems that dysfunction in its activity, not only can increas the base substitution mutations frequency but also can works as a contrived factor to creating instability in genetic materials of the cells. there are several reports about the existence of s...

Journal: :modares journal of medical sciences: pathobiology 2008
behrouz hassannia mehrdad behmanesh mohammad taghi akbari

objective: one of the most significant damages to the genetic material is oxidative deamination of dna and free nucleotides in the cell pool. incorporation of deaminated purine nucleotides such as inosine triphosphate (itp, ditp) into the dna can increase the frequency of base substitution mutation. it has been suggested that presence and accumulation of these rough nucleotides can lead to gene...

Journal: :ChemNanoMat 2022

An enzyme-mimetic nanozyme system is reported that significantly promotes the oxidative deamination of primary amines. This work gives an example valorization 5-hydroxymethylfurfurylamine and glutamic acid, could be applied to any amino acid after optimization reaction conditions.

Abbas Sahebghadam Lotfi, Eskander Omidinia, Hamid Shahbaz Mohammadi, Reza Saghiri,

Amino acid dehydrogenases (L-amino acid: oxidoreductase deaminating EC 1.4.1.X) are members of the wider superfamily of oxidoreductases that catalyze the reversible oxidative deamination of an amino acid to its keto acid and ammonia with the concomitant reduction of either NAD+, NADP+ or FAD. These enzymes have been received much attention as biocatalysts for use in biosensors or diagnostic kit...

Journal: :iranian biomedical journal 0
حمید شهباز محمدی hamid shahbaz mohammadi اسکندر امیدی نیا eskander omidinia عباس صاحبقدم لطفی abbas sahebghadam lotfi رضا صغیری reza saghiri

amino acid dehydrogenases (l-amino acid: oxidoreductase deaminating ec 1.4.1.x) are members of the wider superfamily of oxidoreductases that catalyze the reversible oxidative deamination of an amino acid to its keto acid and ammonia with the concomitant reduction of either nad+, nadp+ or fad. these enzymes have been received much attention as biocatalysts for use in biosensors or diagnostic kit...

Journal: :Rafidain journal of science 2023

Oxidation of inactive prodrug (that their mode action is not via linkage carrier, but occur through modification molecules which are called the bio precursor) to active parent drug design generally methods strategies that aim improve physicochemical and pharmacological properties drugs such as increases bioavailability, water solubility and/or duration action.The goal this review study up-to-da...

Journal: :Journal of Biological Chemistry 1943

Journal: :iranian biomedical journal 0
حمید شهباز محمدی hamid shahbaz mohammadi اسکندر امیدی نیا eskandar omidinia حشمت اله طاهرخانی heshmatollah taherkhani

background: phenylalanine dehydrogenase (phedh ec 1.4.1.20) is a nad+-dependent enzyme that performs the reversible oxidative deamination of l-phenylalanine to phenylpyruvate. it plays an important role in detection and screening of phenylketonuria (pku) diseases and production of chiral intermediates as well. the main goal of this study was to find a simple and rapid alternative method for pur...

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